Effect of Compound Huonaoshu Capsule and Donepezil on Cognitive Function and Serum Cranial Nerves Transmitters in Patients with Mild Cognitive Impairment of Parkinson's Disease
Objective:To observe the effect of Fufang Huonaoshu capsule combined with Donepezil on cognitive function and serum brain neurotransmitters in patients with Parkinson's disease(PD)with mild cognitive impairment(PD-MCI).Methods:128 patients with PD-MCI who received treatment in our hospital from March 2021 to December 2022 were selected.The patients were divided into a control group(treated with Donepezil)and a study group(treated with compound Huonaoshu capsule and Donepezil)according to the method of random number table,with 64 cases in each group.The efficacy,the Mini Mental State Examination(MMSE),the Montreal Cognitive Assessment(MoCA),the Activity of Daily Living Scale(ADL)and serum brain neurotransmitters[5-HT,Acetylcholine,dopamine]were compared between the two groups.Simultaneously observe the incidence of adverse reactions during treatment in both groups.Results:Compared with the control group,the clinical total effective rate of the study group was significantly increased(P＜0.05).After 12 weeks of treatment,the MMSE,MoCA,and ADL scores of the study group were higher than those of the control group(P＜0.05).After 12 weeks of treatment,the 5-HT,Ach,and DA levels in the study group were higher than those in the control group(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Fufang Huonaoshu capsule combined with Donepezil can effectively improve the cognitive function of patients with PD-MCI,improve the serum brain neurotransmitter level,and improve the daily living ability of patients.
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