Effect of Sanjie Analgesic Capsule Combined with Gestrinone on Sex Hormone,Uterine Artery Hemodynamics,and Serum MMPs in Patients with Endometriosis
Objective:To investigate the effect of the combination therapy of gestrinone and Sanjie analgesic capsule on sex hormone,uterine artery hemodynamics,and serum matrix metalloproteinases(MMPs)in patients with endometriosis(EMT).Methods:195 patients with EMT admitted to the Central Theater Command General Hospital of the Chinese People's Liberation Army from January 2021 to December 2022 were selected,and patients were divided into the control group(gestrinone treatment,n=97)and the observation group(Sanjie analgesic capsule combined with gestrinone treatment,n=98)by the dual color sphere method.The efficacy,sex hormone indexes,uterine arterial hemodynamics and serum MMP-2,MMP-3 and MMP-9/tissue inhibitor of matrix metalloproteinase-1(TIMP-1)levels were compared between the two groups,and simultaneously observed the incidence of adverse reactions in both groups.Results:Compared with the control group,the clinical total effective rate of observation group was higher(P＜0.05).After treatment,the follicle stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E2)of the observation group were lower than those of the control group(P＜0.05).After treatment,the pulsatile index(PI)and resistance index(RI)of the observation group were lower than those of the control group,while the peak systolic velocity(PSV)and end-diastolic velocity(EDV)were higher than those of the control group(P＜0.05).After treatment,the MMP-2,MMP-3,MMP-9/TIMP-1 of the observation group were lower than those of the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Sanjie analgesic capsule combined with gestrinone could effectively improve sex hormones,uterine artery hemodynamics,and serum MMP-2,MMP-3,MMP-9/TIMP-1 levels in patients with EMT,and which had good safety.
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