Relationship between the Expression of DCLK1,GPD2,hMTERF3 and Clinicopathological Features and Prognosis in Lung Adenocarcinoma Tissue
Objective:To investigate the relationship between the expression of dicortin-like kinase 1(DCLK1),glycerol-3-phosphate dehydrogenase 2(GPD2),human mitochondrial transcription termination factor 3(hMTERF3)and clinicopathological features and prognosis in lung adenocarcinoma tissue.Methods:125 lung adenocarcinoma patients who were admitted to the Department of Thoracic Surgery of The First Affiliated Hospital of Xinjiang Medical Universityy from June 2017 to June 2020 were selected,the cancer tissues and adjacent tissues(more than 5cm from the cancer tissues)were taken.The expression of DCLK1,GPD2 and hMTERF3 in cancer tissues and adjacent tissues was detected by immunohistochemistry.The relationship between the expression of DCLK1,GPD2,hMTERF3 and the clinicopathological features of lung adenocarcinoma patients were analyzed.The 3-year overall survival(OS)and progression-free survival(PFS)of lung adenocarcinoma patients with different DCLK1,GPD2 and hMTERF3 expression were analyzed by Kaplan-Meier method.Results:The positive expression rates of DCLK1,GPD2 and hMTERF3 in cancer tissues were higher than those in adjacent tissues(P＜0.05).The positive expression rates of DCLK1,GPD2 and hMTERF3 in lung adenocarcinoma tissues with low differentiation,TNM stage Ⅲ A and lymph node metastasis were higher than those in lung adenocarcinoma tissues with middle and high differentiation,TNM stage Ⅰ,Ⅱ and no lymph node metastasis(P＜0.05).The 3-year OS rate and 3-year PFS rate of lung adenocarcinoma patients with positive expression of DCLK1,GPD2 and hMTERF3 were lower than those of lung adenocarcinoma patients with negative expression of DCLK1,GPD2 and hMTERF3(P＜0.05).Conclusion:The positive expression rates of DCLK1,GPD2 and hMTERF3 in lung adenocarcinoma tissues are increase,which are relate to the malignant pathological characteristics and short-term poor prognosis of lung adenocarcinoma.
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