Clinical Efficacy of Xijiao Dihuang Decoction Combined with Conventional Treatment on Acute Cerebral Infarction Patients with Stasis Heat Syndrome and Its Impact on Blood Lipid Levels
Objective:To observe the clinical effect of Xijiao Dihuang Decoction combined with conventional therapy in the treatment of acute cerebral infarction(ACI)with blood stasis heat syndrome and its impact on blood lipid levels in patients.Methods:A prospective study was conducted on 100 ACI patients with blood stasis heat syndrome admitted to the Department of Neurology at the our hospital from January 2021 to December 2022.They were divided into a control group and an observation group using a random number table method,with 50 patients in each group.Patients in the control group were given routine internal medicine treatment,and on this basis,patients in the observation group were given additional treatment with Xijiao Dihuang Decoction.Both groups were treated continuously for 14 days.Compare the clinical efficacy,modified Rankin Scale(mRS)score after treatment,and the National Institutes of Health Stroke Scale(NIHSS)score,blood stasis heat syndrome score,serum lipoprotein associated phospholipase A2(Lp-PLA2),homocysteine(Hcy)score before and after treatment between two groups of patients D-dimer(DD),fibrinogen(FIB),and blood lipids[total cholesterol(TC),triglycerides(TG),low density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)]levels.Results:(1)The NIHSS score,stasis heat syndrome score,and mRS score of the two groups of patients at the end of treatment were reduced,while the observation group had a more significant decrease(P＜0.05).(2)The total effective rate of treatment in the observation group was higher than that in the control group(98.00％vs.92.00％,P＜0.05).(3)At the end of treatment,the serum levels of Lp-PLA2,Hcy,DD,and FIB in the observation group patients and the serum levels of Lp-PLA2,Hcy,and FIB in the control group patients were reduced(P＜0.05).There was no difference in DD levels before and after treatment in the control group patients(P＞0.05).At the end of treatment,the serum levels of Lp-PLA2,Hcy,DD,and FIB in the observation group were lower than those in the control group(P＜0.05).(4)At the end of treatment,the levels of serum TC,TG,and LDL-C in the observation group and the control group were lower than before treatment(P＜0.05).There was no difference in other indicators between the two groups before and after treatment(P＞0.05).The levels of serum TC,TG,and LDL-C at the end of treatment in the observation group were lower than those in the control group(P＜0.05),and there was no difference in serum HDL-C between the two groups at the end of treatment(P＞0.05).Conclusion:Xijiao Dihuang Decoction can significantly improve the clinical efficacy of ACI patients with blood stasis and heat syndrome,alleviate neurological deficits and signs of blood stasis and heat,and improve living ability.This may be related to the further improvement of lipid metabolism and abnormal blood coagulation in patients with Xijiao Dihuang Decoction and the reduction of vascular endothelial damage.
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