Value of Ultrasonic Shear Wave Imaging Combined with Interleukin-10 and Chemokine Receptor 7 in Evaluating the Lesion Nature of Thyroid Diseases
Objective:To evaluate the lesion nature of thyroid diseases with combination of ultrasonic shear wave imaging(2D-SWE)and interleukin-10(IL-10)and chemokine receptor 7(CXCR7).Methods:A total of 89 thyroid patients who underwent thyroid surgery from January 2022 to October 2023 were selected.Preoperative 2D-SWE examination was performed in all patients,and the expression of IL-10 and CXCR7 in postoperative pathologic tissues was detected.To explore the relationship between the expression of 2D-SWE Young's modulus indices EMean,EMax,IL-10 and CXCR7 and the lesion nature of thyroid disease.The risk evaluation model of 2D-SWE combined with IL-10 and CXCR7 to predict the nature of thyroid lesions was established,and the evaluation efficiency of the regression model was analyzed by receiver operating characteristic curve(ROC).Results:Among the 89 thyroid lesions,54 were benign lesions,35 were malignant lesions,33 were IL-10 positive and 33 were CXCR7 positive.Pathological findings were used as the gold standard,and the lesions were divided into benign lesion group(n=54)and malignant lesion group(n=35).The 2D-SWE Young's modulus indices EMean,EMax in the malignant lesion group were higher than those in the benign lesion group,and the positive expression rates of IL-10 and CXCR7 were higher than those in the benign lesion group(P＜0.05).The area under the curve(AUC)(0.95CI)of the regression risk evaluation model constructed by EMean,EMax,IL-10 and CXCR7 was 0.854(0.723～0.982),and the cutoff value was 0.225.Conclusion:The increase of 2D-SWE Young's modulus indices EMean,EMax and IL-10 and CXCR7 positive expression rates is closely related to the nature of thyroid lesions,2D-SWE combined with IL-10 and CXCR7 has certain value in differentiating benign and malignant thyroid diseases.
Thyroid diseasesShear wave elastic imagingIL-10CXCR7Lesion natureEvaluation model
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