Clinical Application Value of Ultrafine Bronchoscopy in 2 Cases of BOS after Allogeneic Hematopoietic Stem Cell Transplantation
Objective:To explore the diagnostic and therapeutic effect of ultra-fine bronchoscopic interventional in bronchiolitis obliterans syndrome(BOS)after allogeneic hematopoietic stem cell transplantation(Allo-HSCT).Methods:Retrospective analysis of clinical data of 2 patients with BOS diagnosed 3 months after transplantation were collected,and the characteristics of diagnosis and therapeutics of BOS were analyzed.Results:The time from Allo-HSCT to diagnosed of BOS in 2 patients in our hospital was within 3 months after transplantation,the clinical manifestations were chest tightness and shortness of breath after activity,and mixed ventilation dysfunction in lung function,Under the direct vision of ultra-fine bronchoscopy,the membrane-like hyperplasia of the lumen orifice of the bronchioles of grade 6 and above in the left and right sides could block the lumen was observed,and the occluded airway could be opened by mechanical expansion or freezing with biopsy forceps,no examination-related complications occurred during and after the operation,the symptoms of the patients were significantly improved compared with the previous ones after treatment,One patient was followed up and the original occluded bronchiole lumen was continuously open after treatment under bronchoscopy.Conclusion:Ultra-fine bronchoscopy can effectively diagnose BOS after Allo-HSCT,and can also open bronchioles through respiratory interventional therapy to improve short-term lung function.
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