The Relationship between Peripheral Blood Inflammatory Factors Expression and Bone Metabolism,Bone DensityLoss in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis
Objective:To explore the relationship between peripheral blood inflammatory factors NLR,IL-1β,TNF-α and bone metabolism indicators bone density,active vitamin D,PTH,ALP and biochemical indicators FPG,2hPG,HbA1c,fasting C-peptide,BMI,blood lipids,blood uric acid in patients with type 2 diabetes mellitus complicated with osteoporosis,and to provide reference for the diagnosis and treatment of such patients.Methods:80 patients with type 2 diabetes mellitus complicated with osteoporosis who visited the endocrinology department of our hospital from September 2020 to September 2021 were selected as the observation group,and 80 healthy physical examination subjects in the same period were selected as the control group.The general data of the two groups of patients were compared.The levels of NLR,IL-1β and TNF-α in peripheral blood of the two groups of patients were detected by ELISA method.The bone density of the two groups of patients was detected by dual-energy X-ray absorptiometry(DEXA).The levels of active vitamin D and PTH in peripheral blood of the two groups of patients were detected by radioimmunoassay.The levels of ALP,FPG,2hPG,HbA1c,fasting C-peptide,BMI,blood lipids and blood uric acid in peripheral blood of the two groups of patients were detected by biochemical analyzer.Results:The levels of NLR,IL-1β and TNF-α in peripheral blood of the observation group were higher than those of the control group(P＜0.05).The bone density of the observation group was lower than that of the control group(P＜0.05).The level of active vitamin D in peripheral blood of the observation group was lower than that of the control group(P＜0.05).The level of PTH in peripheral blood of the observation group was higher than that of the control group(P＜0.05).The level of ALP in peripheral blood of the observation group was higher than that of the control group(P＜0.05).The levels of FPG,2hPG and HbA1c in peripheral blood of the observation group were higher than those of the control group(P＜0.05).The level of fasting C-peptide in peripheral blood of the observation group was lower than that of the control group(P＜0.05).The BMI of the observation group was higher than that of the control group(P＜0.05).The abnormal rate of blood lipids in the observation group was higher than that of the control group(P＜0.05).The level of blood uric acid in the observation group was higher than that of the control group(P＜0.05).The levels of NLR,IL-1β and TNF-α in peripheral blood of the observation group were negatively correlated with bone density(P＜0.05)and active vitamin D(P＜0.05),and positively correlated with PTH and ALP(P＜0.05).There was no significant correlation between NLR,IL-1β and TNF-α in peripheral blood of the observation group and FPG,2hPG,HbA1c,fasting C-peptide,BMI,blood lipids and blood uric acid(P＞0.05).Conclusion:The levels of inflammatory factors NLR,IL-1β and TNF-α in peripheral blood of patients with type 2 diabetes mellitus complicated with osteoporosis are elevated,which may be related to bone metabolism disorder and bone density loss.It suggests that such patients have chronic low-grade inflammation state,and should strengthen the monitoring and intervention on their bone metabolism and bone density,so as to reduce the risk of fracture and improve their quality of life.
Type 2 diabetes mellitusOsteoporosisInflammatory factorsBone metabolismBone density
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