The Effect of Acetylcysteine Combined with Vancomycin in the Treatment of Pediatric Pneumonia and Its Impact on Rehabilitation Indicators and Tidal Breathing Indicators of Pediatric Patients
Objective:To explore the efficacy of acetylcysteine combined with vancomycin in the treatment of pediatric pneumonia and its impact on rehabilitation indicators and tidal breathing indicators in pediatric patients.Methods:110 children with pneumonia admitted to our hospital from May 2020 to May 2023 were selected and divided into a matched group and an observation group based on different treatment methods,with 55 cases in each group.They were treated with vancomycin and combined with acetylcysteine,respectively.The clinical efficacy,disappearance time of main symptoms(fever,cough,lung rale),absorption time of thoracic inflammation,and tidal breathing indicators[tidal volume(VT),peak to peak time ratio(TPTEF/TE),peak to volume ratio(VPEF/VE),and respiratory rate(RR)]Serum inflammatory factors such as C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),procalcitonin(PCT),and adverse reactions were compared between the two groups.Results:The disappearance time of main symptoms such as fever,cough,lung rales,and the absorption time of chest inflammation in the observation group were shorter than those in the matched group(P＜0.05).After treatment,VT,TPTEF/TE,VPEFNE increased in both groups of children,while RR and serum CRP,TNF,IL-6,and PCT levels significantly decreased(P＜0.05).After treatment,the VT,TPTEF/TE,VPEF/VE levels of the observation group were higher than those of the matched group,while the RR and serum CRP,TNF,IL-6,and PCT levels were lower than those of the matched group(P＜0.05).The recovery rate of the observation group was higher than that of the matched group(94.55％vs.78.18％,P＜0.05),and the total effective rate(100.00％vs.96.36％)and incidence of adverse reactions(10.91％vs.9.09％)were not different from the matched group(P＞0.05).Conclusion:Acetylcysteine combined with vancomycin has a high therapeutic effect on pediatric pneumonia,which can improve the tidal and respiratory indicators of children,reduce the inflammatory response of the body,accelerate the relief of symptoms and signs,and have good safety.
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