Effects of Longlu Pills Combined with Letrozole on Sex Hormone,Th1/Th2 Immune Imbalance and Clinical Outcome in Infertility Patients with Polycystic Ovary Syndrome
Objective:To investigate the effects of longlu pills combined with letrozole on sex hormones,helhelper T cell 1/helper T cell 2(Th1/Th2)immune imbalance and clinical outcome in infertile patients with polycystic ovary syndrome(PCOS).Methods:135 PCOS infertility patients who were treated in Hunan Provincial Maternal and Child Health Hospital from April 2020 to April 2023 were selected.Patients were divided into control group and combined group by double chromosphere method,67 cases and 68 cases respectively.Control group was treated with letrozole,and combined group was treated with longlu pills combine with letrozole.The efficacy,sex hormone indexes[estradiol(E2),follicle stimulating hormone(FSH),progesterone(P)and luteinizing hormone(LH)],Th1/Th2 immune imbalance related indexes[interferon γ(IFN--γ),interleukin 4(IL-4)and Th1/Th2],clinical outcome and safety were compared between two groups.Results:Compared with control group,the total clinical effective rate in combined group was higher(P＜0.05).After treatment,E2,FSH and P in combined group were higher than those in control group,and LH was lower than that in control group(P＜0.05).After treatment,IFN-γ,IL-4 and Th1/Th2 in combined group were lower than those in control group(P＜0.05).The ovulation rate and pregnancy rate in combined group were higher than those in control group(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:PCOS infertility patients treat with longlu pill combined with letrozole,which can improve their clinical outcomes by better improving sex hormone levels and improving disease resistance.
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