Effects of Brucea Javanica Oil Emulsion Injection Combined with TP Regimen on Tumor Markers and Serum TAP and Hsp90α in Patients with Advanced Non-Small Cell Lung Cancer
Objective:To investigate the effects of brucea javanica oil emulsion injection combined with cisplatin and paclitaxel(TP)regimen on tumor markers,serum tumor abnormal protein(TAP)and heat shock protein 90α(Hsp90α)in patients with advanced non-small cell lung cancer(NSCLC).Methods:A total of 100 patients with advanced NSCLC who were admitted to the Department of Respiratory,Respiratory Hospital Area of Brain Hospital Affiliated to Nanjing Medical University from March 2018 to March 2020 were included.Randomized number table method was used in the groups,among them,50 cases in the study group were treated with on the basis of TP regimen combined with brucea javanica oil emulsion injection,and 50 cases in the control group were treated with TP regi-men alone.Efficacy,serum tumor markers,TAP,Hsp90α and incidence of adverse reactions were compared in the two groups.After 3 years of follow-up,the cumulative survival rate in the two groups was analyzed by the survival curve.Results:The objective remission rate and disease control rate in the study group were higher than those in the control group(P＜0.05).4 cycles after treatment,carcinoem-bryonic antigen(CEA),squamous cell carcinoma antigen(SCC),TAP,cytokeratin 19 fragment(CYFRA21-1)and Hsp90α in the study group were lower than those in the control group(P＜0.05).There was no difference in the incidence of adverse reactions in the two groups(P＞0.05).The progression-free survival time(PFS)and overall survival time(OS)in the two groups were tested by LogRank,all had significant differences(P＜0.05).Conclusion:Brucea javanica oil emulsion injection combined with TP regimen in the treatment of patients with advanced NSCLC can effectively regulate tumor markers and serum TAP and Hsp90α levels,and prolong the survival rate of patients.
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