Multivariate Analysis of Plasma Aβ Levels Affecting Patients with Type 2 Diabetes Mellitus
Objective:To explore the factors affecting plasma β-amyloid(Aβ)level in patients with type 2 diabetes mellitus(T2DM).Methods:415 patients with T2DM who were hospitalized in the Department of Endocrinology and Geriatrics of the Ninth Hos-pital of Xi'an were selected.Another 176 patients matched for age,gender,education level,history of macrovascular disease(history of heart disease),without diabetes,and meeting the exclusion criteria were selected as the control group(NC group).Plasma Aβ40 and Aβ42 levels were measured using ELISA,and the correlation between blood glucose and plasma Aβ40 and Aβ42 levels was assessed by Pearson correlation analysis,and the factors affecting Aβ40 and Aβ42 levels were assessed by Multivariate linear regression analysis.Results:Com-pared with the NC group,patients in the T2DM group had significantly higher levels of fasting blood glucose(FBG),glycated hemoglobin(HbAlc)and triglyceride(TG)(P＜0.05),and significantly lower levels of high-density lipoprotein(HDL)and low-density lipoprotein(LDL)(P＜0.05);plasma Aβ40 levels were significantly higher(P=0.002),but plasma Aβ42 levels were significantly lower(P＜0.001).Plasma Aβ42 levels were significantly lower in T2DM patients with cognitive abnormalities compared with T2DM patients with normal cognitive function(P=0.025);FBG was negatively correlated with plasma Aβ42 levels in T2DM patients(r=-0.099,P=0.016);and multiple linear regression analyses showed that HDL and TG levels were the factors influencing plasma Aβ40 levels(P=0.002,P=0.027)and also affected plasma Aβ42 levels(P=0.004).Conclusion:Plasma Aβ40 levels were significantly higher and plasma Aβ42 levels were significantly lower in patients with T2DM.Plasma Aβ42 levels were significantly lower in T2DM patients with concomitant cogni-tive abnormalities.HDL and TG levels are factors that influence plasma Aβ levels.
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