Relationship between Serum VEGF,HPSE,HIF-1α and Visual Prognosis in Patients with Central Retinal Vein Occlusion after Ranibizumab Treatment
Objective:To study the relationship between serum vascular endothelial growth factor(VEGF),heparanase(HPSE),hypoxia inducible factor-1α(HIF-1α)and visual prognosis in patients with central retinal vein occlusion(CRVO)after ranibizumab treat-ment.Methods:145 CRVO patients admitted to the Department of Ophthalmology,Affiliated Hospital of Guizhou Medical University from January 2020 to August 2022 were selected,patients were divided into good prognosis group(n=104)and poor prognosis group(n=41)according to the visual prognosis situation after ranibizumab treatment.The clinical data and serum levels of VEGF,HPSE and HIF-1 α were compared between good prognosis group and poor prognosis group.The influencing factors of visual prognosis after ranibizumab treatment in CRVO patients were analyzed by multivariate Logistic regression model,the predictive value of serum VEGF,HPSE and HIF-1α on the visual prognosis of CRVO patients after ranibizumab treatment was analyzed by receiver operating characteris-tic(ROC)curve.Results:Compared with the good prognosis group,the age,the proportion of ischemic type CRVO,the proportion of combined with hypertension,the proportion of combined with hyperlipidemia,the proportion of persistent macular edema and serum VE GF,HPSE,HIF-1α levels were higher in the poor prognosis group,and course of CRVO was longer,and the best corrected visual acuity at initial diagnosis was lower(all P＜0.05).Multivariate logistic regression analysis showed that low best corrected visual acuity at initial diagnosis,persistent macular edema,ischemic type CRVO and elevated serum VEGF,HPSE and HIF-1α were risk factors for poor visual prognosis in CRVO patients after ranibizumab treatment(P＜0.05).The area under the curve(AUC)of serum VEGF,HPSE and HIF-1αalone and in combination in predicting the visual prognosis of CRVO patients after ranibizumab treatment was 0.726,0.777,0.836 and 0.891 respectively,the efficacy of combined prediction was significantly better than that of single detection(P＜0.05).Conclusion:In CR-VO patients,the higher the levels of serum VEGF,HPSE and HIF-1α,the worse the visual prognosis after ranibizumab treatment.The combination of the three indicators has a high value in predicting the visual prognosis in CRVO patients after ranibizumab treatment,which is expected to be used as a prognostic indicator for CRVO.
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