Exploring the Therapeutic Effectiveness and Mechanism of the Combination of Alamod and Hydroxychloroquine Sulfate in the Treatment of Rheumatoid Arthritis Based on Inflammatory Immune Regulation
Objective:To explore the therapeutic effectiveness and mechanism of the combination of alamod and hydroxychloro-quine sulfate in the treatment of rheumatoid arthritis(RA)based on inflammatory immune regulation.Methods:A total of 120 RA pa-tients were admitted to the Tianyou Hospital Affiliated to Wuhan University of Science and Technology and Wuhan Fourth Hospital from April 2021 to March 2023.According to the random number table method,patients were divided into a control group and a study group,with 60 cases in each group.The control group patients received hydroxychloroquine sulfate treatment,while the study group patients re-ceived combination therapy with alamod and hydroxychloroquine sulfate.Compared the therapeutic effectiveness,clinical symptom relief time,and inflammatory factors[tumor necrosis factor α(TNF-α)],Interleukin-6(IL-6),interferon α(IFN-α),Interferon-γ(IFN-γ)],Vi-sual Pain Simulation Scale(VAS)and Simplified Healthy Quality of Life(SF-36),immune function factors[T lymphocyte subpopula-tions(CD4+,CD8+,CD4+/CD8+),immunoglobulins(Ig)G,M,A]between two groups.Simultaneously observed the safety of medication in both groups.Results:Compared with the control group,the clinical total effective rate of the study group was higher(P＜0.05).The re-lief time of arthralgia,arthroncus,morning stiffness of joint in study group were shorter than those in control group(P＜0.05).After 6 months of treatment,both groups of TNF-α,IL-6,IFN-y,IFN-α decreased,and the study group was lower than the control group(P＜0.05).After 6 months of treatment,CD8+increased in both groups,and the study group was higher than the control group;CD4+and CD4+/CD8+decreased,and the study group was lower than the control group(P＜0.05).After 6 months of treatment,IgG,IgM,and IgA decreased in both groups,and the study group was lower than the control group(P＜0.05).After 6 months of treatment,the VAS scores of both groups decreased,and the study group was lower than the control group;The SF-36 score increased,and the study group was higher than the control group(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclu-sion:The combination of Alamod and hydroxychloroquine sulfate in the treatment of RA has a definite therapeutic effectiveness,which can shorten the symptom relief time,relieve joint pain and improve the quality of life of patients,and the medication is safe with few side effects.The mechanism of action may be related to the regulation of inflammatory response and immune response.
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