Relationship between Serum HMGB1,CTCs and AAPR with Postoperative Biochemical Recurrence in Patients Undergoing Laparoscopic Radical Prostatectomy
Objective:To investigate the relationship between serum high mobility group protein B1(HMGB1),circulating tumor cells(CTCs)and albumin/alkaline phosphatase ratio(AAPR)and postoperative biochemical recurrence in patients undergoing laparo-scopic radical prostatectomy(LRP).Methods:169 patients with LRP admitted to the Second Affiliated Hospital of Soochow University from January 2018 to July 2020 were selected,and they were divided into biochemical recurrence group and non-biochemical recurrence group according to the occurrence of postoperative biochemical recurrence.Serum HMGB1,peripheral blood CTCs were detected,and AAPR was calculated.Multivariate Logistic regression was used to analyze the influencing factors of postoperative biochemical recur-rence in patients with LRP,and the predictive value of serum HMGB1,CTCs and AAPR for postoperative biochemical recurrence in pa-tients with LRP was analyzed by receiver operating characteristics(ROC)curve.Results:After 2 years of follow-up,the incidence rate of postoperative biochemical recurrence in 169 patients with LRP was 25.44％(43/169).Compared with non-biochemical recurrence group,serum HMGB1 and CTCs in the biochemical recurrence group were higher,and AAPR was lower(P＜0.05).Multivariate Logistic re-gression analysis showed that Clinical stage T2 stage,prostate specific antigen(PSA)＞20 ng/mL,elevated HMGB1 and CTCs,Gleason score 8 scores were independent risk factors for postoperative biochemical recurrence in patients with LRP.The elevated free prostate specific antigen/total prostate specific antigen(fPSA/tPSA)and AAPR were independent protective factors(P＜0.05).ROC curve analy-sis showed that the area under the curve predicted by serum HMGB1 combined with CTCs and AAPR for postoperative biochemical re-currence in LRP patients was 0.881,which was greater than that predicted by HMGB1,CTCs,and AAPR alone.Conclusion:Serum HMGB1,CTCs and AAPR are independently correlated with postoperative biochemical recurrence in patients with LRP.Serum HMGB1 combine with CTCs and AAPR has a high value in predicting postoperative biochemical recurrence in patients with LRP,and which may be an auxiliary predictor of postoperative biochemical recurrence in patients with LRP.
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