Analysis of the Relationship between Serum NGAL,HMGB1,Gal-3 and Disease Activity and Carotid Atherosclerosis in Systemic Lupus Erythematosus Patients
Objective:To analyze the relationship between serum neutrophil gelatinase associated lipocalin(NGAL),high mobility group protein B1(HMGB1),galectin-3(Gal-3)and disease activity and carotid atherosclerosis(CAS)in systemic lupus erythematosus(SLE)patients.Methods:160 SLE patients who were admitted to Xuzhou Central Hospital from January 2020 to March 2023 were se-lected as study subjects.The levels of serum NGAL,HMGB1 and Gal-3 were detected by enzyme-linked immunosorbent assay.Accord-ing to SLE disease activity index(SLEDAI)score,the patients were divided into inactive group(n=48),severe activity group(n=32),moderate activity group(n=39)and mild activity group(n=41).And patients were divided into CAS group(n=56)and non-CAS group(n=104)according to the results of carotid color Doppler ultrasonography.The differences of serum NGAL,HMGB1 and Gal-3 levels in each group were compared.Multiple Logistic regression analysis was used to investigate the influencing factors occurrence of CAS in SLE.Results:The levels of serum NGAL,HMGB1 and Gal-3 in inactive group,mild activity group,moderate activity group and severe activity group increased in turn,and overall comparison difference was statistically significant(P＜0.05).The levels of serum NGAL,HMGB1 and Gal-3 in CAS group were higher than those in non-CAS group(P＜0.05).Multivariate logistic regression analysis showed that,high NGAL,high HMGB1,high Gal-3,high age and long course of SLE were risk factors for CAS in SLE patients,while standard-ized application of hydroxychloroquine drug therapy was protective factor(P＜0.05).Conclusion:The levels of serum NGAL,HMGB1 and Gal-3 in SLE patients increase with the severity of the disease.At the same time,high NGAL,HMGB1,Gal-3,age and long course of SLE are risk factors for CAS in SLE patients.
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