Relationship between Serum Amyloid A,Neutrophil/Lymphocyte Ratio,Platelet/Lymphocyte Ratio and Postoperative Incision Infection in Children with Acute Suppurative Appendicitis
Objective:To investigate the relationship between serum amyloid A(SAA),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and postoperative incision infection in children with acute suppurative appendicitis.Methods:418 chil-dren with acute suppurative appendicitis were selected,and the incision infection was observed within 7 d after operation,patients were divided into infected group and uninfected group according to whether postoperative infection occurred.Preoperative serum SAA,NLR and PLR were compared between infected group and uninfected group.The influencing factors of postoperative incision infection were analyzed by univariate and multivariate Logistic regression models.The predictive value of preoperative serum SAA,NLR and PLR for postoperative incision infection were evaluated by receiver operating characteristic(ROC)curve.Results:418 children with acute suppu-rative appendicitis,54 had postoperative incision infection,with an infection rate of 12.92％.The preoperative serum SAA,NLR and PLR in infected group were higher than those in uninfected group(P＜0.05).Postoperative incision infection was related to operation time and operation method(P＜0.05).And not related to gender,age,incision length,and the average time from onset to surgery(P＞0.05).Long preoperative operation time,elevated serum SAA,elevated NLR,elevated PLR,and operation method was laparotomy were risk factors for postoperative incision infection(P＜0.05).The efficacy of combined detection of preoperative serum SAA,NLR and PLR in predicting postoperative incision infection was greater than that of each index alone.Conclusion:Preoperative serum SAA level,NLR and PLR are elevate in children with incision infection after acute suppurative appendicitis,the combine detection in three indicators has a high predictive efficiency for postoperative incision infection occurrence,serum SAA,NLR,PLR,operation time and operation method are the influencing factors of postoperative incision infection.
Acute suppurative appendicitisChildrenIncision infectionSerum Amyloid ANeutrophil/Lymphocyte ratioPlatelet/Lymphocyte ratio
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