Diagnostic Value of CYFRA21-1,MMP-3 and CEA Combined with Cytology in Malignant Pleural Effusion
Objective:To study Diagnostic value of Cytokeratin 19 fragment(CYFRA21-1),matrix metalloproteinase-3(MMP-3)and carcinoembryonic antigen(CEA)combined with cytology in malignant pleural effusion.Methods:100 patients with pleural effusion admitted to our hospital from January 2020 to January 2023 were selected for study,and were divided into experimental group(47 cases with malignant pathological examination results)and control group(53 cases with benign pathological examination results)according to pathological findings.The changes of serum CYFRA21-1,MMP-3,CEA and cytology levels and their diagnostic value were analyzed.Results:The serum levels of CYFRA21-1,MMP-3 and CEA in experimental group were significantly higher than those in control group(P＜0.05).The positive rates of CYFRA21-1,MMP-3,CEA and cytology in experimental group were significantly higher than those in control group(P＜0.05).The AUC of CYFRA21-1 in the diagnosis of malignant pleural effusion was 0.989,95％CI was 0.977～1.000.The AUC and 95％CI of MMP-3 in the diagnosis of malignant pleural effusion were 0.979 and 0.964-0.994.The AUC for CEA diagnosis of malignant pleural effusion was 0.982,95％CI was 0.967～0.997.The AUC and 95％CI for the diagnosis of malignant pleural effusion were 0.823,0.766～0.879,and the AUC and 95％CI for combined detection were 0.995 and 0.990～1.000,which were significantly differ-ent from the area under the curve for single detection.The specificity and accuracy are higher than that of single detection.Conclusion:CYFRA21-1,MMP-3 and CEA combined with cytology can effectively improve the accuracy of diagnosis of malignant pleural effusion,and have high clinical application value.
Cytokeratin 19 fragmentMatrix metalloproteinase-3Carcinoembryonic antigenCytologyMalignant pleural effusionDiagnostic value
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