Relationship between Serum CTRP5,CTRP12,CTRP13 and Glycolipid Metabolism and Carotid Atherosclerosis in Elderly Patients with Type 2 Diabetes Mellitus
Objective:To investigate the relationship between serum complement 1q/tumor necrosis factor-related protein(CTRP)5,CTRP12,CTRP 13 and glycolipid metabolism and carotid atherosclerosis(CAS)in elderly patients with type 2 diabetes mellitus(T2DM).Methods:198 elderly patients with T2DM who were admitted to The Affiliated Hospital ofXuzhou Medical University from January 2021 to January 2023 were selected as T2DM group,and 100 healthy elderly people during the same period were selected as control group,elderly patients with T2DM were divided into CAS group(n=131)and non-CAS group(n=67)according to whether CAS occurred or not.Serum CTRP5,CTRP12,CTRP13 and glycolipid metabolism indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hBG),glycosylated hemoglobin(HbA1c),homeostasis model assessment-insulin resistance index(HOMA-IR),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]were de-tected.The correlation between serum CTRP5,CTRP 12,CTRP 13 and glycolipid metabolism indexes in elderly patients with T2DM were analyzed by Pearson correlation analysis.The influencing factors of CAS in elderly patients with T2DM and the diagnostic value of serum CTRP5,CTRP12 and CTRP13 levels were analyzed by multivariate Logistic regression model and receiver operating characteris-tic(ROC)curve.Results:Compared with control group,the levels of serum CTRP5,FPG,2hBG,HbA1c,HOMA-IR,TC,TG and LDL-C in T2DM group were increased,and the levels of CTRP12,CTRP13 and HDL-C were decreased(P＜0.05).Pearson correlation analysis showed that,serum CTRP5 was positively correlated with FPG,2 hBG,HbA1c,HOMA-IR,TC,TG and LDL-C levels,and neg-atively correlated with HDL-C level in elderly patients with T2DM(P＜0.05).Serum CTRP12 and CTRP13 were negatively correlated with FPG,2hBG,HbA1c,HOMA-IR,TC,TG and LDL-C levels,and positively correlated with HDL-C levels(P＜0.05).Multivariate Lo-gistic regression model analysis showed that,elevated HbA1c,HOMA-IR,LDL-C and CTRP5 were independent risk factors for CAS in elderly patients with T2DM,and elevated CTRP12 and CTRP13 were independent protective factors(P＜0.05).ROC curve analysis showed that,the area under the curve(AUC)of serum CTRP5,CTRP12 and CTRP13 levels combined in the diagnosis of CAS in elderly patients with T2DM was 0.915,which was greater than 0.790,0.785 and 0.789 of serum CTRP5,CTRP12 and CTRP13 levels alone.Conclusion:The level of serum CTRP5 in elderly patients with T2DM is increase,and the levels of CTRP12 and CTRP13 are decrease,which is closely relate to glycolipid metabolism disorders and CAS,the combination of serum CTRP5,CTRP12 and CTRP13 levels has a high diagnostic value for CAS in elderly patients with T2DM.
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