Effects of Different Doses of Dexmedetomidine Combined with Ropivacaine TAPB on Immune Inflammatory Response and Cognitive Function in Patients Undergoing Laparoscopic Inguinal Hernia Repair
Objective:To investigate the effects of different doses of dexmedetomidine combined with ropivacaine transversus abdominis plane block(TAPB)on immune inflammatory response and cognitive function in patients undergoing laparoscopic inguinal hernia repair.Methods:150 patients with laparoscopic inguinal hernia repair who were admitted to the Second People's Hospital of Hefei from March 2020 to March 2022 were divided into group A(n=75)and group B(n=75)according to the random number table method.Both groups were treated with dexmedetomidine combined with ropivacaine TAPB,group A was given 0.5 μg/kg dexmedetomidine and group B was given 1 μg/kg dexmedetomidine.The hemodynamics,visual analogue scale(VAS),mini-mental state examination(MMSE)score,incidence of postoperative cognitive dysfunction(POCD),inflammatory response and immune function related indicators were compared in two groups.Results:Compared with group A at the beginning of operation 1 h(T1)and immediately after the end of op-eraion(T2),mean arterial pressure(MAP)and heart rate(HR)were lower in group B(P＜0.05).The incidence of POCD in group B was lower than that in group A(P＜0.05).Compared with group A1d and 2 d after operation,the MMSE score in group B was higher(P＜0.05).Compared with group A at 12 h,24 h and 48 h after operation,the VAS score in group B was lower(P＜0.05).Compared with group A 2 d after operation,CD8+was lower,and CD3+,CD4+and CD4+/CD8+were higher in group B(P＜0.05).Compared with group A 2 d after operation,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)were lower in group B(P＜0.05).Conclu-sion:Anesthesia with 1 μg/kg dose of dexmedetomidine combined with ropivacaine TAPB in patients undergoing laparoscopic inguinal hernia repair,which can reduce pain,alleviate the degree of immune inflammatory response,maintain hemodynamic stability,and reduce the incidence of POCD.
DexmetomidineRopivacaineTAPBLaparoscopic inguinal hernia repairInflammatory responseImmune functionCognitive function
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