Effect of Dexamethasone Combined with Ropivacaine ESP Block on Pain in Elderly Patients after Radical Mastectomy for Breast Cancer
Objective:To investigate the effect of dexamethasone combined with ropivacaine ESP block on pain in elderly patients after radical mastectomy for breast cancer.Methods:A total of 110 elderly female patients who underwent elective radical mastectomy for breast cancer in Shiyan Dongfeng General Hospital,Hubei Province from September 2020 to May 2023were selected as the research subjects.They were divided into ESP group and control group according to random number table,with 55 cases in each group.The control group received general anesthesia,while ESP group received ESP block.The two groups were compared on perioperative indicators,NRS scores in resting state at 1 h,6 h,12 h,24 h and 48 h after operation,serum 5-hydroxytryptamine(5-HT)and prostaglandin E2(PGE2)levels before and after operation,and occurrence of postoperative adverse reactions.Results:Comparison between the groups found that operation time and ambulation time of ESP group was significantly shorter(P＜0.05).Intraoperative blood loss of ESP group was less(P＞0.05).NRS scores of both groups gradually increased and then decreased at 1 h,6 h,12 h,24 h and 48 h after operation.The NRS score of ESP group was lower than that of the control group at each time point.The decreases in ESP group were significantly greater than those in control group over time.There were statistically significant differences in NRS scores in terms of inter-group effect,time effect and interaction effect(P＜0.05).After operation,serum 5-HT and PGE2 levels in ESP group were significantly lower(P＜0.05).The incidence rates of dizziness,nausea and vomiting,and skin pruritus were lower in ESP group,but there was no statistically significant difference compared to control group(P＞0.05).Conclusion:Applying dexamethasone combined with ropivacaine ESP block to elderly patients undergoing radical mastectomy for breast cancer can effectively alleviate postoperative pain.The analgesic effect may be related to reduction of 5-HT and PGE2 levels.In addition,this analgesic mode is highly safe.
DexamethasoneRopivacaineESP blockElderlyRadical mastectomy for breast cancerPostoperative pain
NETL
NSTL
万方数据
