Effect of Salmeterol Fluticasone Combined with Budesonide Inhalation Aerosol on Bronchial Asthma and Treg T Cell Subsets
Objective:To investigate the effect of salmeterol fluticasone combined with budesonide inhalation aerosol on bronchial asthma and Treg T cell subsets.Methods:Eighty patients with bronchial asthma admitted from June 2021 to April 2023 were selected and divided into observation group and matched group,40 each.The matched group was treated with salmeterol fluticasone in-halation,and the observation group was treated with salmeterol fluticasone combined with budesonide inhalation aerosol inhalation.The signs and symptoms disappeared time,tumor necrosis factor pretherapy and 1 month post-treatment were compared between the two groups(tumor necrosis factor-α(TNF-α),Interferon-γ(IFN-γ),The expression levels of interleukin-6(IL-6)and T cell subsets were de-tected,and the incidence of adverse reactions was compared between the two groups.Results:In the observation group,the disappear-ance time of wet rales and cough were shorter than that of the matched group(P＜0.05);pretherapy,There was no difference in TNF-α,IFN-y,and IL-6 levels between the two groups(P＞0.05),Both were decreased after the treatment,And,when compared with the matched group,The value was lower in the observation group(P＜0.05);There was no difference in CD4+,CD3+and CD4+/CD8+values between the two previous treatment groups(P＞0.05),CD4+,CD3+,and CD4+/CD8+values were increased in the post/treatment observation group,And the observation group was higher than the matched group(P＜0.05);There was no difference in the incidence of adverse reac-tions between the two groups(P＞0.05).Conclusion:The application effect of salmeterol fluticasone combined with budesonide inhalation aerosol in the treatment of bronchial asthma is significant,which can shorten the duration of symptoms and signs of patients,reduce the reaction of inflammatory factors,and improve the ratio of T cell subsets,with high safety.
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