Effects of Sevoflurane Combined with Dexmedetomidine Epidural Anesthesia on Recovery Quality,Oxidative Stress and Inflammatory State in Children Undergoing Inguinal Hernia Repair
Objective:To observe the effects of sevoflurane combined with dexmedetomidine epidural anesthesia on recovery quality,oxidative stress and inflammatory state in children undergoing inguinal hernia repair.Methods:From June 2021 to June 2023,124 children who underwent laparoscopic inguinal hernia repair in Shijiazhuang Maternal and Child Health Hospital were selected.Ac-cording to the random number table method,children were divided into control group and observation group,with 62 cases in each group,they received sevoflurane and epidural anesthesia and sevoflurane combined with dexmedetomidine epidural anesthesia respec-tively.The hemodynamic indexes,recovery quality,inflammatory factors,oxidative stress factors and anesthesia-related adverse reactions were compared between two groups.Results:At the time point of intubation(T1)to the end of operation(T2),compared with control group,the hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)]in observation group were lower(P＜0.05).Compared with control group,the recovery time,spontaneous breathing recovery time and extubation time in observation group were shorter(P＜0.05).1 day after operation,compared with control group,the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β)]and malondialdehyde(MDA)in observation group were lower,and superoxide dismutase(SOD)was higher(P＜0.05).There was no significant difference in the incidence of adverse reactions between control group(11.29％)and observation group(9.68％)(P＞0.05).Conclusion:Sevoflurane combined with dexmedetomidine epidural anesthesia for children with inguinal hernia repair,which can stabilize the hemodynamics of children,improve recovery quality,and reduce oxidative stress and inflammatory state.
SevofluraneDexmedetomidineEpidural anesthesiaInguinal hernia repairRecovery qualityOxidative stressInflam-matory state
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