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住院老年人骨骼肌质量指数与TG/HDL-C的相关性研究

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目的:分析住院老年人骨骼肌质量指数(ASMI)与甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)的相关性,评估TG/HDL-C对老年住院患者发生低ASMI的预测价值。方法:选取2022年7月至2023年8月兰州大学第一医院收治的299例住院老年患者,根据2019年亚洲肌少症工作组发布的关于肌少症的诊疗共识,分为低ASMI组(105例)和正常ASMI组(194例)。比较2组的临床资料,通过Spearman相关分析研究ASMI与相关变量之间的相关性,通过多因素Logistic回归分析ASMI的影响因素,采用受试者工作特征(ROC)曲线评估TG/HDL-C对老年住院患者发生低ASMI的预测价值。结果:随着ASMI的增加,TG/HDL-C比值增加(P<0。001)。Spearman相关分析显示,ASMI与腰臀比、基础代谢、肌肉、握力、体脂率、BMI、ALT、TG、TG/HDL-C均成正相关(P<0。05),与HDL-C成负相关(P<0。05)。多因素分析显示:体脂率、尿酸、TG/HDL-C是ASMI的独立影响因素。ROC曲线显示,TG/HDL-C曲线下面积为0。67(95%CI:0。607~0。722)。结论:高TG/HDL-C是低ASMI的保护因素。TG/HDL-C对低ASMI的发生有一定的预测价值,通过简单易得的血脂指标来估计骨骼肌质量易于实现,对可疑早期肌少症患者进行监测与干预。
Correlation between Skeletal Muscle Mass Index and TG/HDL-C in Hospitalized Elderly
Objective:To analyze the correlation between skeletal muscle mass index(ASMI)and TG/HDL-C in hospitalized el-derly patients.To evaluate the predictive value of TG/HDL-C for low ASMI in elderly hospitalized patients.Methods:A total of 299 hos-pitalized elderly patients admitted to the First Hospital of Lanzhou University from July 2022 to August 2023 were selected and divided into low ASMI group(105 cases)and normal ASMI group(194 cases)according to the consensus on the diagnosis and treatment of sar-copenia issued by the Asian Working Group on sarcopenia in 2019.Clinical data of the two groups were compared,Spearman correlation analysis was used to study the correlation between ASMI and related variables,and multi-factor Logistic regression was used to analyze the influencing factors of ASMI.the predictive value of TG/HDL-C in the occurrence of low ASMI in elderly hospitalized patients was evaluate by receiver operating characteristic(ROC)curve.Results:With the increase of ASMI,TG/HDL-C ratio increased(P<0.001).Spearman correlation analysis showed that ASMI was positively correlated with waist-to-hip ratio,basal metabolism,muscle,grip strength,body fat percentage,BMI,ALT,TG,TG/HDL-C,and negatively correlated with HDL-C(P<0.05).Multifactor analysis showed that body fat percentage,uric acid and TG/HDL-C were independent influencing factors of ASMI.ROC curve showed that the area under TG/HDL-C curve was 0.67(95%CI:0.607~0.722).Conclusion:High TG/HDL-C was protective factors for low ASMI.TG/HDL-C has certain predictive value for the occurrence of low ASMI,and it is easy to estimate skeletal muscle mass by simple and easily obtained lipid indexes,so early monitoring and intervention can be carried out for patients with suspected sarcopenia.

Skeletal muscle mass indexSarcopeniaTG/HDL-CBlood fat

杨柳、和娇娇、蒋琪、党彩虹、李维辛

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兰州大学第一临床医学院 甘肃兰州 730000

兰州大学第一医院 甘肃兰州 730000

骨骼肌质量指数 肌少症 甘油三酯与高密度脂蛋白胆固醇比值 血脂

甘肃省自然科学基金

22JR5RA925

2024

现代生物医学进展
黑龙江省森工总医院 哈尔滨医科大学附属第四医院

现代生物医学进展

CSTPCD
影响因子:0.755
ISSN:1673-6273
年,卷(期):2024.24(9)
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