The Effect of Pterostilbene on Neuronal Apoptosis during Brain Edema after Ischemia Reperfusion Injury in Mice
Objective:To explore the effect of pterostilbene on neuronal apoptosis during brain edema after ischemia reperfusion injury in mice.Methods:The experimental mice were randomly divided into three groups:sham group,IR group and PTE+IR group.The dose of PTE was injected intraperitoneally with 5 mg/kg once a day for 5 days totally.The cerebral infarct image was stained by TTC and the cerebral infarct volume was measured by Image J after IR 3 d.The neurological behavioral scores were tested after IR1/12,1/2,1,2,4,6,8,10,12 and 14 d.The neuronal apoptotic percentage of cerebral ischemic penumbra and ipsilateral hippocampus were detected by TUNEL detection kit after IR3,7 and 14 d.Results:PTE lowered cerebral infarct volume,improved neurological behavioral scores and inhibited neuronal apoptosis of cerebral ischemic penumbra and ipsilateral hippocampus.Conclusions:PTE presents a continuous neuro-protective effect against ischemia reperfusion during cerebral edema in mice by suppression of cell apoptosis.
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