Correlation Analysis of Serum IL-10,IL-17,IL-33 and the Relative Abundance of Intestinal Flora and Cognitive Function in Patients with Alzheimer's Disease
Objective:To analyze the correlation between serum interleukin(IL)-10,IL-17,IL-33 and relative abundance of in-testinal flora and cognitive function in patients with Alzheimer's disease(AD).Methods:98 AD patients admitted to Geriatrics Depart-ment of Ninth People's Hospital,Shanghai Jiaotong University School of Medicine and Neurology Department of Huangpu Branch from April 2020 to April 2023 were selected as study subjects.AD patients were divided into mild group(n=36),moderate group(n=39)and severe group(n=23)according to the clinical dementia rating scale(CDR).The IL-10,IL-17,IL-33,relative abundance of intestinal flora and cognitive function scores in three groups were compared.The correlation between serum IL-10,IL-17,IL-33 and relative abundance of intestinal flora and cognitive function in AD patients were analyzed by Pearson correlation analysis.Results:The levels of IL-17 in se-vere group and moderate group were higher than those in mild group,and severe group was higher than that of moderate group(P＜0.05).The levels of IL-10 and IL-33 in severe group and moderate group were lower than those in mild group,and severe group was lower than that of moderate group(P＜0.05).The clostridia,firmicutes,clostridaceae,and clostridiales in severe group and moderate group were lower than those in mild group,and severe group was lower than that of moderate group(P＜0.05).The bacteroidetes,bacteroides,bacteroides and alcaligenes in severe group and moderate group were higher than those in mild group,and severe group was higher than that of mod-erate group(P＜0.05).The MMSE scores in severe group and moderate group were lower than those in mild group,and severe group was lower than that of moderate group(P＜0.05).Pearson correlation analysis showed that,IL-10 and IL-33 were positively correlated with MMSE score,firmicutes,clostridia,clostridiales and clostridaceae,and negatively correlated with bacteroidetes,bacteroidetes,bac-teroidetes and alcaligenes(P＜0.05).IL-17 was negatively correlated with MMSE score,firmicutes,clostridia,clostridiales and clostri-daceae,and positively correlated with bacteroidetes,bacteroidetes,bacteroidetes and alcaligenes(P＜0.05).Conclusion:The cognitive function of AD patients decreased,the levels of serum IL-10,IL-17 and IL-33 changed abnormally,and the relative abundance of intesti-nal flora in patients was abnormal,and the levels of IL-10,IL-17 and IL-33 were correlate with the relative abundance of intestinal flora and cognitive function.
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