Effect of Yishen Huoxue Decoction Combined with Bailing Capsule on Renal Function,Calcium and Phosphorus Metabolism and T Lymphocyte Subsets in Patients with Chronic Renal Failure
Objective:To investigate the effect of Yishen Huoxue decoction combined with Bailing capsule on renal function,cal-cium and phosphorus metabolism and T lymphocyte subsets in patients with chronic renal failure.Methods:102 patients with chronic re-nal failure in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,from May 2020 to March 2022 were selected,and randomly divided into control group(conventional western medicine treatment)and observation group(Yishen Huoxue de-coction combined with Bailing capsule on the basis of the control group)by random number table method,51 cases in each group.Both groups were treated for 8 weeks.The curative effect and the changes of traditional Chinese medicine syndrome score,renal function,cal-cium and phosphorus metabolism and T lymphocyte subsets before and 8 weeks after treatment were compared between the two groups.Results:The observation group's total effective rate at 8 weeks after treatment was 92.16％(47/51),which was higher than 74.51％(38/51)of the control group(P＜0.05).After 8 weeks of treatment,the traditional Chinese medicine main symptom score and secondary symp-tom score in the two groups were decreased,and compared to the control group,the observation group was lower(P＜0.05).After 8 weeks of treatment,serum creatinine,urea nitrogen and 24 h proteinuria in the two groups were lower than those before treatment,and the observation group was lower than those in the control group(P＜0.05).After 8 weeks of treatment,CD8+was decreased in the two groups,and the observation group was lower than the control group(P＜0.05),while CD4+,CD3+,CD4+/CD8+were increased compared with those before treatment,and the observation group was higher than the control group(P＜0.05).After 8 weeks of treatment,the blood phosphorus and calcium phosphorus product decreased in both groups,and compared to the observation group,the control group was higher(P＜0.05).The blood calcium was increased,and compared to the control group,the observation group was higher(P＜0.05).Conclu-sion:Yishen Huoxue decoction combined with Bailing capsule in the treatment of patients with chronic renal failure can improve renal function,improve calcium and phosphorus metabolism and T lymphocyte subsets,and relieve their clinical symptoms,the curative effect is definite and worthy of clinical reference and application.
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