Effect of Olaparib Maintenance Therapy on Serum Tumor Markers and Apoptosis Factors in Patients with Platinum Sensitive Recurrent Ovarian Cancer
Objective:To observe the effect of olaparib maintenance therapy on serum apoptosis factors and tumor markers in patients with platinum sensitive recurrent ovarian cancer.Methods:According to the random number table method,80 patients with plat-inum sensitive recurrent ovarian cancer who were admitted to our hospital from January 2020 to January 2022 were divided into control group(n=40)and observation group(n=40).Patients in both groups were treated with second-line platinum-containing chemotherapy,after clinical remission or partial remission was evaluated,patients in control group were not treated with special drugs,while patients in observation group began to take Olaparib orally as maintenance treatment within 8 weeks after chemotherapy until disease progression or unacceptable toxicity.The levels of serum tumor markers and apoptotic factors were compared between two groups,and the incidence of adverse reactions and prognosis were observed.Results:Carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125 and human epididymis protein 4(HE4)in two groups decreased after treatment(P＜0.05),and the observation group was lower than that in control group after treatment(P＜0.05).B-cell lymphoma-2(Bcl-2),soluble apoptosis factor(sFas)and Bcl-2 binding anti-apoptotic gene-1(Bag-1)decreased,and Bcl-2 related X protein(Bax)increased in both groups after treatment(P＜0.05),Bcl-2,sFas and Bag-1 in obser-vation group were lower than those in control group,and Bax was higher than that in control group after treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between two groups during treatment(P＞0.05).After treatment,Cognitive ability,Emotional health,Social function,Physical function,and Behavioral function scores increased in both groups,and the improve-ment in the observation group was greater than that in the control group(P＜0.05).Conclusion:Olaparib maintenance therapy in patients with platinum sensitive recurrent ovarian cancer can effectively improve the levels of serum tumor markers and apoptotic factors,im-prove the quality of life of patients and have a good prognosis.
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