Study on the Correlation between Serum PGRN,SFRP1,CCL26,Lung Function,and Airway Inflammation in Children with Acute Exacerbation of Bronchial Asthma
Objective:To analyze the correlation between serum progranulin(PGRN),secreted frizzled related protein 1(SFRP1),chemokine cytokines ligand 26(CCL26),lung function,and airway inflammation in children with acute exacerbation of bronchial asth-ma.Methods:129 children with acute exacerbation of bronchial asthma(acute group)who were treated in our hospital from July 2019 to December 2022 were selected.According to lung function examination and combined with clinical characteristics,the children were di-vided into mild group(n=51),moderate group(n=42)and severe group(n=36).And another 60 children with clinical remission of bronchial asthma(control group)who came to our hospital for treatment during the same period were selected.The serum PGRN,SFRP1,CCL26,lung function and airway inflammation of children with bronchial asthma in the control group and each subgroup of acute group were compared.Pearson correlation was used to analyze the correlation between serum PGRN,SFRP1,CCL26 and lung function indexes and airway inflammation indexes.Results:The PGRN in the severe group,moderate group and mild group was lower than that in the control group,SFRP1 and CCL26 were higher than that in the control group(P＜0.05).With the increase of the severity of the disease,the PGRN of children with bronchial asthma decreased continuously,and SFRP1 and CCL26 increased continuously(P＜0.05).Forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and maximum peak expiratory flow rate(PEF)in the severe group,moderate group and mild group were lower than those in the control group(P＜0.05).FVC,FEV,and PEF in children with bronchial asthma decreased continuously with the increase of the severity of the disease(P＜0.05).The interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)in the severe group,moderate group and mild group were higher than those in the control group(P＜0.05).The IL-8,TNF-α and IL-17 in children with bronchial asthma increased continuously with the increase of the severity of the disease(P＜0.05).The results of Pearson correlation analysis showed that PGRN was positively correlated with lung func-tion indexes,and negatively correlated with airway inflammation indexes(P＜0.05).SFRP1 and CCL26 were negatively correlated with lung function indexes,and positively correlated with airway inflammation indexes(P＜0.05).Conclusion:Serum PGRN is decreased ab-normally in children with acute exacerbation of bronchial asthma,and SFRP1 and CCL26 are increased abnormally,which are involved in the severity of the disease,and they are correlated with lung function and airway inflammation.
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