Study on the Improvement Effect of Yuchuang Zicao Oil on Radiation-Induced Skin Mucosal Injury Caused by Radiotherapy in Patients with Head and Neck Malignant Tumors
Objective:To explore the clinical effect of Yuchuang Zicao oil in improving radiation-induced skin mucosal injury caused by radiotherapy in patients with head and neck malignant tumor,so as to provide a new treatment method for radiation-induced skin mucosal injury caused by radiotherapy in patients with head and neck malignant tumor.Methods:A total of 100 patients with head and neck malignant tumors radiotherapy from March 2021 to March 2023 in Lu'an Hospital Affiliated to Anhui University of Traditional Chinese Medicine were selected as the research objects.The random number table was randomly divided into observation group and con-trol group,50 cases in each group.Both groups were treated with conformal intensity modulated radiation therapy,the control group was given routine radiotherapy skin management and education,while the observation group was treated with Yuchuang Zicao oil on the ba-sis of the control group.The degree of skin mucosal injury,clinical efficacy,completion rate of radiotherapy,healing time of skin lesions,numerical rating scale(NRS)score,Karnofsky performance status(KPS)score,and dermatology life quality index(DLQI)score at 2,4,and 6 weeks of radiotherapy;levels of inflammatory cytokines[interleukin-6(IL-6),procalcitonin(PCT),high-sensitivity C-reactive pro-tein(hs-CRP)]before radiotherapy and at 6 weeks of radiotherapy,and side effects were compared between the two groups.Results:The degree of skin mucosal injury in the observation group was lower than that in the control group(P＜0.05).The total effective rate of the observation group was 94.00％higher than that of the control group 80.00％(P＜0.05).At 4 and 6 weeks of radiotherapy,the NRS score and DLQI score of the observation group were lower than those of the control group,and the KPS score was higher than that of the control group(P＜0.05).The completion rate of radiotherapy in both groups was 100％,and the skin lesion healing time in the observation group was shorter than that in the control group(P＜0.05).The levels of serum IL-6,PCT and hs-CRP in the observation group were low-er than those in the control group at 6 weeks of radiotherapy(P＜0.05).There were no skin adverse reactions such as rash,redness and itching caused by allergies in both groups.Conclusion:Yuchuang Zicao oil can effectively reduce the radiation-induced skin mucosal in-jury caused by radiotherapy for head and neck malignant tumor,reduce the level of serum inflammatory cytokines,promote the skin lesion healing time and improve the quality of life,and it has significant curative effect and high safety.
Yuchuang Zicao oilHead and neck tumorsRadiotherapyRadiation-induced skin mucosal injuryClinical efficacy
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