Expression and Clinical Significance of Serum ROCK1 and HDAC3 in Patients with Chronic Heart Failure with Atrial Fibrillation
Objective:To investigate the expression and clinical significance of serum Rho associated coiled coil containing pro-tein kinase 1(ROCK1)and histone deacetylase 3(HDAC3)in patients with chronic heart failure(CHF)with atrial fibrillation(AF).Methods:312 CHF patients admitted to Puren Hospital Affiliated to Wuhan University of Science and Technology from January 2021 to September 2022 were selected,patients were divided into AF group(n=1 15)and no AF group(n=197)according to whether patients had AF,and CHF patients with AF were divided into poor prognosis group and good prognosis group according to the different prognosis.The levels of serum ROCK1,HDAC3 and cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-dias-tolic diameter(LVEDD),left atrial diameter(LAD)]were compared between AF group and no AF group.The correlation between serum ROCK1,HDAC3 levels and cardiac function indexes in CHF patients with AF were analyzed by Pearson correlation analysis,the influ-encing factors of poor prognosis in CHF patients with AF were analyzed by multivariate Logistic regression analysis,the predictive value of serum ROCK1 and HDAC3 levels for poor prognosis in CHF patients with AF was analyzed by receiver operating characteristic(ROC)curve.Results:Compared with no AF group,the levels of serum ROCK1 and HDAC3,LVEDD and LAD were increased,and LVEF was decreased in AF group(P＜0.05).Pearson correlation analysis showed that,serum ROCK1 and HDAC3 levels in CHF patients with AF were negatively correlated with LVEF,and positively correlated with LVEDD and LAD(P＜0.05).After 3 months of follow-up,the incidence of poor prognosis in 115 patients with AF was 26.96％.Multivariate Logistic regression analysis showed that,New York Heart Association cardiac function grade≥Ⅲ and elevated N-terminal pro-B-type natriuretic peptide(NT-proBNP),ROCK1,and HDAC3 were independent risk factors for poor prognosis in CHF patients with AF(P＜0.05).ROC curve analysis showed that,the area under the curve of serum ROCK1 and HDAC3 levels combined prediction the poor prognosis of CHF patients with AF was 0.897,which was greater than that of single index prediction.Conclusion:The expression of serum ROCK1 and HDAC3 in CHF patients with AF were increased,which were closely relate to cardiac function and prognosis,the combination of serum ROCK1 and HDAC3 had a high value in predicting the poor prognosis of CHF patients with AF.
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