The Expression Levels of Serum BDNF and TLR4 in Patients with Different Types of Neuropathic Pain and Their Diagnostic Value were Analyzed
Objective:To analyze the expression levels of serum brain-derived neurotrophic factor(BDNF)and Toll receptor 4(TLR4)in patients with different types of neuropathic pain(NP)and their diagnostic value.Methods:A total of 80 NP patients and 100 healthy subjects admitted to our hospital from May 2021 to May 2022 were selected as the study subjects.NP patients were included in the NP group,and healthy subjects were included in the control group.The neuropathic pain scale(NPS)was used to distinguish the na-ture of pain in the NP group(20 cases of dull pain,28 cases of discomfort,17 cases of deep pain,and 15 cases of body surface pain).The expression levels of serum BDNF and TLR4 in the two groups of patients and patients with different types of pain in the NP group were detected.Bivariate Spearman correlation was used to test the correlation between serum BDNF,TLR4 and different types of pain in NP.At the same time,a multivariate Logistic model was established to analyze the influencing factors of different types of pain in NP and compare their diagnostic efficacy.Results:Compared with the control group,the expression level of serum BDNF in NP group was lower,and the expression level of TLR4 was higher(P＜0.05).There were significant differences in the expression levels of serum BDNF and TLR4 in NP dull pain,discomfort,deep pain and body surface pain(P＜0.05).Serum BDNF was negatively correlated with NP dull pain,discomfort,deep pain and body surface pain,while serum TLR4 was positively correlated with NP dull pain,discomfort,deep pain and body surface pain(P＜0.05).Logistic multivariate analysis showed that BDNF and TLR4 were independent risk factors for NP dull pain,discomfort,deep pain and body surface pain(P＜0.05).The ACU of serum BDNF,TLR4 and BDNF+TLR4 for NP dull pain,discomfort,deep pain and body surface pain were all＞0.70.Conclusion:Serum BDNF and TLR4 are associated with NP of blunt pain,discomfort,deep pain,and body surface pain.They have high sensitivity and specificity in the diagnosis of different NP properties,which is benefi-cial to provide reference for clinical treatment.
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