Analysis of the Diagnostic Value of Transvaginal Ultrasound Combined with Serum AFP,PAI-1,and MMIF in Endometriosis
Objective:To explore the diagnostic value of transvaginal ultrasound combined with serum alpha fetoprotein(AFP),plasminogen activator inhibitor-1(PAI-1),and macrophage migration inhibitory factor(MMIF)in endometriosis.Methods:A retrospec-tive analysis was conducted on 150 patients with endometriosis admitted to our hospital from August 2021 to August 2023.The imaging features of transvaginal ultrasound were analyzed,and pathological diagnosis was used as the"gold standard"to analyze the positive de-tection rate of vaginal ultrasound for endometriosis.According to the staging of endometriosis,it was divided into stage Ⅰ-Ⅱ group(n=77)and stage Ⅲ-Ⅳ group(n=73).In addition,150 healthy women who came to our hospital for physical examination during the same period were selected as the control group.Analyze the expression levels of serum AFP,PAI-1,and MMIF in three groups of subjects,and use Spearman correlation analysis to analyze the correlation between AFP,PAI-1,and MMIF and endometriosis.Finally,a receiver charac-teristics(ROC)working curve was established to analyze the diagnostic efficacy of transvaginal ultrasound combined with serum AFP,PAI-1,and MMIF for endometriosis.Results:All 150 patients with endometriosis were diagnosed by pathology,and 128 patients(85.33％)were diagnosed with endometriosis through transvaginal ultrasound examination.Among them,75 patients were ovarian type,and ultrasound showed a huge chocolate cyst with a large amount of fine dotted echoes and separated light bands inside.53 patients were of uterine type,and ultrasound showed a posterior wall adenomyoma with uneven internal echoes and visible patchy anechoic areas;There were significant differences in the expression levels of serum AFP,PAI-1,and MMIF among the three groups of subjects.The lev-els of serum AFP,PAI-1,and MMIF in the stage Ⅲ-Ⅳ group were significantly higher than those in the stage Ⅰ-Ⅱ group and the control group,and the difference was statistically significant(P＜0.05);Spearman correlation analysis showed that AFP,PAI-1,and MMIF were positively correlated with endometriosis(P＜0.05);The diagnostic sensitivity and specificity from low to high were MMIF(52.58％,64.32％),PAI-1(60.03％,67.53％),AFP(65.24％,71.27％),transvaginal ultrasound(73.25％,86.36％),transvaginal ultrasound com-bined with serum AFP,PAI-1,and MMIF(84.26％,98.63％).The diagnostic sensitivity of transvaginal ultrasound combined with serum AFP,PAI-1,and MMIF was significantly higher than that of single indicator diagnosis(P＜0.05).Conclusion:Transvaginal ultrasound combined with serum AFP,PAI-1,and MMIF has a high diagnostic value for endometriosis,with sensitivity and specificity of 84.26％and 98.63％,respectively.Through combined diagnosis,it can further assist in reducing the probability of misdiagnosis and missed diag-nosis of endometriosis,providing important reference for the diagnosis and treatment of endometriosis.
NETL
NSTL
万方数据
