Effect of Huoxue Lishui Decoction on Visual Function,Macular Thickness,Serum and Vitreous Fluid HIF-1α,sICAM-1 Expression in Patients with Diabetic Macular Edema
Objective:To investigate the effects of Huoxue Lishui Decoction on visual function,macular thickness,expression of hypoxia-inducible factor-1α(HIF-1α)and soluble intercellular adhesion molecule-1(sICAM-1)in serum and vitreous fluid in patients with diabetic macular edema(DME),so as to provide reference for optimizing the treatment of DME.Methods:80 patients with DME from June 2022 to June 2023 in Suining Traditional Chinese Medicine Hospital Affiliated to North Sichuan Medical College and Panzhi-hua Integrated Traditional Chinese and Western Medicine Hospital were randomly divided into control group and observation group,40 cases in each group.The control group was treated with conbercept,and the observation group was treated with Huoxue Lishui Decoc-tion on the basis of the control group.The TCM syndrome scores,clinical efficacy,best corrected visual acuity(BCVA),central foveal thickness(CFT),serum and vitreous fluid HIF-1α,sICAM-1 expression,and incidence of toxic and side effects were compared between the two groups.Results:After treatment,the scores of TCM syndromes in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P＜0.05).The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the BCVA of the two groups was higher than that before treatment,and that of the observation group was higher than that of the control group(P＜0.05).After treatment,the CFT of the two groups was lower than that before treatment,and that of the observation group was lower than the control group(P＜0.05).After treatment,the levels of serum and vitreous fluid HIF-1α and sICAM-1 in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P＜0.05).There was no significant difference in the incidence of toxic and side effects between the two groups(P＞0.05).Conclusion:Huoxue Lishui Decoction is effective in the adjuvant treatment of DME patients.It can reduce the TCM syndrome score,improve the visual acuity of the affected eye,reduce macular edema,inhibit the levels of HIF-1α and sICAM-1 in serum and vitreous fluid,and has high safety.
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