Evaluation Value of Ultrasound Combined with NT-proBNP and TUG1 in Elderly Patients with Hypertension and Heart Failure with Preserved Ejection Fraction
Objective:To investigate the clinical value of echocardiography combined with N-terminal pro-brain natriuretic pep-tide(NT-proBNP)and long non-coding RNA(lncRNA)taurine-upregulated gene 1(TUG 1)in elderly patients with hypertension and heart failure with preserved ejection fraction(HFPEF).Methods:82 elderly patients with hypertension and HFPEF who were diagnosed and treated in Handan First Hospital from March 2021 to March 2022 were selected as the study group.According to new York Heart Association(NYHA)cardiac function classification,the patients were divided into subgroup A(Ⅰ～Ⅱ)48 cases and subgroup B(Ⅲ～Ⅳ)34 cases.In addition,74 elderly patients with hypertension without HFPEF who were examined during the same period were selected as the control group.The cardiac ultrasound parameters of all subjects were recorded,and their serum NT-proBNP and TUG1 levels were detected.Receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of ultrasound parameters combined with NT-proBNP and TUG1 in elderly patients with hypertension and HFPEF,and to evaluate the value of ultrasound parameters in eval-uating the severity of elderly patients with hypertension and HFPEF.Results:The left atrial diameter(LAD),serum NT-proBNP and TUG-1 levels in study group were higher than those in control group,and the ratio of early diastolic mitral flow velocity to late diastolic mitral flow velocity(E/A)was lower than that in control group(P＜0.05).The LAD,NT-proBNP and TUG1 levels in subgroup B were higher than those in subgroup A,and E/A was lower than that in subgroup A(P＜0.05).The results of ROC curve analysis showed that the area under the curve(AUC),sensitivity and specificity of LAD,E/A combined with serum NT-proBNP and TUG1 in the evaluation of elderly hypertension with HFPEF were 0.876,0.854 and 0.838,respectively.At the same time,the AUC,sensitivity and specificity of LAD,E/A combined with serum NT-proBNP and TUG1 in evaluating the severity of elderly hypertension with HFPEF were 0.851,0.853 and 0.833,respectively,the combined evaluation efficiency was better than that of each index alone.Conclusion:Cardiac ultrasound parameters,NT-proBNP and TUG-1 have certain clinical value in the diagnosis and evaluation of elderly hypertensive patients with HFPEF,and LAD,E/A parameters combined with serum NT-proBNP and TUG-1 have higher value.
ElderlyHypertensionHeart failure with preserved ejection fractionColor doppler ultrasoundNT-proBNPTUG1Di-agnostic value
NETL
NSTL
万方数据
