Correlation and Predictive Value of Serum Irisin,SOST and H2S with Bone Density and Bone Metabolism Markers in Patients with Knee Osteoarthritis Combined with Osteoporosis
Objective:To investigate the correlation between serum irisin(Irisin),sclerostin(SOST),hydrogen sulfide(H2S)and bone density and bone metabolism markers in patients with knee osteoarthritis(KOA)combined with osteoporosis(OP),and to analyze the predictive value of Irisin,SOST,and H2S for KOA complicated with OP.Methods:179 KOA patients who were admitted to our hos-pital from April 2020 to April 2023 were selected,and patients were divided into OP group(68 cases)and non-OP group(111 cases)ac-cording to whether they were combine with OP.The levels of serum Irisin,SOST,H2S and bone metabolism markers osteocalcin(OC),bone alkaline phosphatase(BALP),type Ⅰ procollagen N-terminal propeptide(PINP),tartrate-resistant acid phosphatase allogenic(TRACP5b),bone density of femoral neck and lumbar spine L1～4 were detected.The correlation between serum Irisin,SOST,H2S and bone density of femoral neck and lumbar spine L1～4 and serum bone metabolic markers were analyzed by Pearson,the predictive value of serum Irisin,SOST and H2S for KOA combine with OP were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum Irisin,H2S,OC,BALP and PINP,bone density of femoral neck and lumbar spine L1～4 in OP group were lower than those in non-OP group(P＜0.05),while the levels of TRACP and SOST were higher than those in non-OP group(P＜0.05).Serum Irisin and H2S levels in OP group were positively correlated with bone density of femoral neck and lumbar spine L1～4,serum OC,BALP and PINP levels(P＜0.05),and negatively correlated with serum TRACP level(P＜0.05).SOST level was negatively correlated with bone den-sity of femoral neck and lumbar spine L1～4,serum OC,BALP and PINP levels(P＜0.05),and positively correlated with serum TRACP level(P＜0.05).The area under the curve of Irisin,SOST and H2S in predicting KOA combined with OP was 0.784,0.773 and 0.755 respectively,the area under the curve of combined prediction of KOA combine with OP was 0.908,which was higher than that of single prediction.Conclusion:Serum Irisin and H2S levels decreased and SOST levels increased in patients with KOA combined with OP.Low levels of Irisin,H2S and high levels of SOST are associated with decreased bone mineral density and abnormal bone metabolism,which can be used to predict abnormal bone metabolism and risk of bone loss in patients with KOA combine with OP.
Knee osteoarthritisOsteoporosisIrisinSOSTH2SBone densityBone metabolismCorrelationPredictive value
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