Relationship between RDW,D-D,S100A12 and the Disease Condition and Clinical Outcome in Patients with Acute Non-Variceal Upper Gastrointestinal Bleeding
Objective:To investigate the relationship between red blood cell distribution width(RDW),D-dimer(D-D),S100 cal-cium binding protein 12(S100A12)and disease condition and clinical outcome in patients with acute non-variceal upper gastrointestinal bleeding(ANVUGIB).Methods:184 ANVUGIB patients admitted to The First People's Hospital of Guiyang from July 2021 to August 2023 were selected as study group,and 100 healthy individuals who underwent physical examinations during the same period were se-lected as control group.Patients were divided into low-risk group(28 cases),middle-risk group(60 cases)and high-risk group(96 cases)according to the Rockall risk score,and patients were divided into poor prognosis group(66 cases)and good prognosis group(118 cases)according to the clinical outcome during hospitalization.RDW,plasma D-D and serum S100A12 levels were detected.The risk factors of poor clinical outcomes in ANVUGIB patients were analyzed by multivariate Logistic regression analysis.Results:The levels of RDW,plasma D-D and serum S100A12 in study group were higher than those in control group(P＜0.05).The levels of RDW,plasma D-D and serum S100A12 in high-risk group were significantly higher than those in middle-risk group and low-risk group,and the levels of RDW,plasma D-D and serum S100A12 in middle-risk group were significantly higher than those in low-risk group(P＜0.05).The levels of RDW,plasma D-D and serum S100A12 in poor outcome group were higher than those in good outcome group(P＜0.05).Multivariate Logistic regression analysis showed that,increased Rockall risk score,bleeding volume＞1000 mL,increased RDW,increased plasma D-D and increased serum S100A12 were risk factors for poor clinical outcomes in ANVUGIB patients(P＜0.05).Conclusion:The levels of RDW,D-D and S100A12 in ANVUGIB patients are closely relate to the patient's disease condition and clinical outcome.Increase RDW,increase plasma D-D and increase serum S100A12 are risk factors for poor clinical outcomes in ANVUGIB patients.
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