Relationship between Serum ANXA2,ANXA6,ANXA7 and the Efficacy of Polyethylene Glycol Doxorubicin Liposome-Related Neoadjuvant Chemotherapy in Breast Cancer Patients
Objective:To investigate the relationship between serum annexin A2(ANXA2),annexin A6(ANXA6),annexin A7(ANXA7)and the efficacy of polyethylene glycol doxorubicin liposome(PLD)-related neoadjuvant chemotherapy in breast cancer pa-tients.Methods:95 breast cancer patients who were underwent PLD-related neoadjuvant chemotherapy in the First Hospital of Shanxi Medical University from November 2019 to December 2022 were selected.The levels of serum ANXA2,ANXA6 and ANXA7 in all breast cancer patients were detected before neoadjuvant chemotherapy.The factors affecting the efficacy of PLD-related neoadjuvant chemotherapy in breast cancer patients were analyzed by univariate and multivariate Logistic regression analysis.The value of serum ANXA2,ANXA6 and ANXA7 in predicting the efficacy of PLD-related neoadjuvant chemotherapy in breast cancer patients were ana-lyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum ANXA2,ANXA6 and ANXA7 before neoadjuvant chemotherapy in ineffective group were higher than those in effective group(P＜0.05).TNM stage ⅢA,ER positive,high level of ANX-A2,high level of ANXA6 and high level of ANXA7 were risk factors for the failure of PLD-related neoadjuvant chemotherapy in breast cancer(P＜0.05).The area under the curve of serum ANXA2,ANXA6 and ANXA7 alone in predicting the failure of PLD-related neoad-juvant chemotherapy for breast cancer was 0.783,0.774 and 0.821,respectively,the area under the curve predicted by the combined de-tection of the three indicators was 0.923,which was higher than that of each indicator alone.Conclusion:The high levels of ANXA2,ANXA6 and ANXA7,TNM stage ⅢA and ER positive are all risk factors for the failure of PLD-related neoadjuvant chemotherapy in breast cancer patients.Combined detection of serum ANXA2,ANXA6 and ANXA7 levels can improve the predictive efficacy of PLD-related neoadjuvant chemotherapy in breast cancer patients.
Breast cancerNeoadjuvant chemotherapyPolyethylene glycol doxorubicin liposomeANXA2ANXA6ANXA7Pre-dictive value
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