Plasma Untargeted Metabolomics of Small Lung Cancer Cell Based on Liquid Chromatography-High Resolution Mass Spectrometry
Objective:Conduct metabolomic research on the plasma of patients with small cell lung cancer to characterize their baseline metabolic characteristics and provide basic metabolic data and clues for the treatment of small cell lung cancer.Methods:Based on liquid chromatography couple with quadrupole time-of-fight mass spectrometry,plasma untargeted metabolomics studies and metabolic characterization on 53 controls(healthy people)and 48 patients with small cell lung cancer were developed.Results:The plasma metabolism was significantly altered in patients with small cell lung cancer at baseline compared to controls and a total of 113 differential metabolites were identified.The 59 up-regulated metabolites such as 2'-deoxyguanosine 5'-monophosphate(FC=9.17),cyclic adenosine monophosphate(FC=7.72),and inosine(FC=6.38),and 54 down-regulated metabolites such as 2-aminobenzoic acid(FC=0.24),glutathione(FC=0.27)and xanthine(FC=0.29),mainly participated in amino acid metabolism.Conclusions:Metabolic profiling was changed significantly between patients with small cell lung cancer and controls.The discovery of relevant differential metabolites and pathways will help promote the development of new targeted drugs for small cell lung cancer,thereby improving the current situation of limited treatment options and lack of targeted treatments.
Small Cell Lung CancerPlasmaMetabolomicsHigh Resolution Mass Spectrometry
NETL
NSTL
万方数据
