The Effect of Nrf2/ARE Signaling Pathway and Oxidative Stress in Coronary Heart Disease Treated by Tanshinone
Objective:To analyze the effect of tanshinone inhibiting oxidative stress and myocardial injury in patients with coronary heart disease through nuclear factor E2 related factor 2(Nrf2)/antioxidant response element(ARE)signaling pathway.Methods:A prospective study was conducted on 84 patients with unstable angina pectoris diagnosis in our hospital from June 2022 to June 2023.They were randomly divided into control group and observation group,with 42 patients in each group.The control group received conventional drugs and intervention,while the observation group received tanshinone ⅡA sulfonate sodium injection(40 mg/d)on the basis of control group for 2 weeks continuous treatment.Comparisons of peripheral blood Nrf2,ARE,and hypoxia inducible factor-1α(HIF-1α)and Caspase-1 proteins expression,oxidative stress indicators such as reactive oxygen species(ROS),malondialdehyde(MDA),and superoxide dismutase(SOD),inflammatory mediators tumor necrosis factor(TNF)-α and interleukin(IL)-1β,myocardial injury indicators troponin Ⅰ(cTnⅠ)and creatine kinase isoenzyme(CK-MB)were made between two groups before and after treatment.Results:There were no differences of above indicators between the two groups before treatment(P＞0.05).After treatment,there were significant improvements compared to before treatment(P＜0.05),and the expressions of Nrf2 and ARE proteins in observation group were significantly higher than those in control group,while HIF-1α and Caspase-1 proteins expression were significantly lower than control group,ROS level was less,MDA and SOD levels were higher,TNF-α and IL-1β levels were less,cTnⅠ and CK-MB levels were lower,too(P＜0.05).Conclusion:Tanshinone may inhibit oxidative stress,inflammatory response,cell apoptosis,and myocardial injury in patients with coronary heart disease by activating Nrf2/ARE signaling pathway.
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