Rehabilitation Effect of Acupuncture Combined with Joint Loosening Manipulation on Patients with Ankle Fracture after Operation and its Effect on Bone Metabolism Indexes and Serum IL-1β,IL-8 and MMP-13
Objective:To observe the rehabilitation effect of acupuncture combined with joint loosening manipulation on patients with ankle fracture after operation and its effect on bone metabolism indexes and serum interleukin(IL)-1 β,IL-8 and matrix metalloproteinase(MMP)-13.Methods:138 patients with ankle fractures who were treated in the Third Affiliated Hospital of Southern Medical University from March 2020 to March 2023 were selected.Patients were divided into control group(receiving routine rehabilitation training combine with joint loosening manipulation,n=69)and study group(receiving acupuncture treatment on the basis of control group,n=69)according to the random number table method.The changes of visual analogue scale(VAS),American Orthopaedic Foot and Ankle Society(AOFAS)score,ankle dorsiflexion and plantar flexion activity,serum IL-1β,IL-8,MMP-13 and bone metabolism indexes[osteocalcin(BGP),bone alkaline phosphatase(BALP),β-collagen degradation products(β-CTX)]were compared between two groups.Result:1 month after treatment,the VAS score in study group was lower than that in control group,and the AOFAS score was higher than that in control group(P＜0.05).1 month after treatment,the activity of dorsal extension and plantar flexion in study group were higher than those in control group(P＜0.05).1 month after treatment,the levels of IL-1β,IL-8 and MMP-13 in study group were lower than those in control group(P＜0.05).1 month after treatment,β-CTX in study group was lower than that in control group,BGP and BALP were higher than those in control group(P＜0.05).Conclusion:The application of acupuncture combine with joint loosening manipulation on patients with ankle fracture after operation,which can effectively reduce the level of inflammatory factors and the degree of pain,and promote the improvement of ankle function and bone metabolism.
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