Analysis of the Relationship between Protein Expression of Slug,TdT and SOX9 and Clinicopathological Features and Prognosis in Thymoma Tissues
Objective:The relationship between the expression of zinc finger transcription factor(Slug),terminal deoxyribonucleotidyl transferase(TdT),Y chromosome sex determination region related high-speed swimming frame factor 9(SOX9)protein and clinicopathological features and prognosis of thymoma patients was analyzed.Methods:113 cases of thymoma tissues and adjacent tissues surgically resected in our hospital were selected from May 2016 to November 2018.The positive expression of Slug,TdT and SOX9 protein was determined by immunohistochemistry.The relationship between the expression of Slug,TdT and SOX9 protein and the clinicopathological features and prognosis of thymoma patients was analyzed.Results:The positive expression rates of Slug,TdT and SOX9 protein in thymoma tissues were higher than those in adjacent tissues(P＜0.05).There was no significant difference in the positive expression of Slug,TdT and SOX9 protein in thymoma tissues in terms of age,gender,tumor diameter,whether combined with myasthenia gravis and whether accompanied by macrovascular invasion(P＞0.05).The positive expression of Slug,TdT and SOX9 protein in thymoma tissues was significantly different in Masaoka-Koga stage and WHO classification(P＜0.05).The positive expression of Slug,TdT and SOX9 protein in thymoma tissues was positively correlated with Masaoka-Koga stage and WHO classification(P＜0.05).The 5-year overall survival rate in 113 thymoma patients was 81.42％(92/113),the 5-year survival rate in Slug positive group was lower than that in Slug negative group(70.18％VS 92.86％).the 5-year survival rate in TdT positive group was lower than that in TdT negative group(79.790％VS 89.57％),the 5-year survival rate in SOX9 positive group was lower than that in SOX9 negative group(79.35％VS 90.48％)(x2=9.669,9.515,17.008,P＜0.05).Cox proportional hazard regression model analysis showed that,Masaoka-Koga stage(stageⅢ/stageⅣ),WHO classification(B2/B3),positive expression of Slug protein,positive expression of TdT protein and positive expression of SOX9 protein were independent risk factors affecting the prognosis of thymoma patients(HR:3.518,2.921,4.536,1.402,2.921,P＜0.05).Conclusion:The expression of Slug,TdT and SOX9 in thymoma tissues are high,the expression of the three proteins are relate to the Masaoka-Koga stage and WHO classification,and they are independent risk factor affecting the 5-year survival rate of thymoma patients.
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