Effects of Shenqi Fuzheng Injection Combined with Cisplatin and Pemetrexed on Tumor Markers,Th1/Th2 Cytokines,and Serum miR-29b and miR-221 in Patients with Advanced Non-Small Cell Lung Cancer
Objective:To investigate the effects of shenqi fuzheng injection combined with cisplatin and pemetrexed on tumor markers,helper T cell(Th)1/Th2 cytokines and serum microRNA(miR)-29b and miR-221 in patients with advanced non-small cell lung cancer(NSCLC).Methods:131 patients with advanced NSCLC who were admitted to Fujian Provincial Hospital from March 2020 to December 2022 were divided into control group(cisplatin and pemetrexed treatment,n=65)and study group(shenqi fuzheng injection combined with cisplatin and pemetrexed treatment,n=66)according to the random number table method.The efficacy,tumor marker levels,Th1/Th2 cytokines,serum miR-29b and miR-221 expression levels were compared between two groups,and the incidence of adverse reactions was observed.Results:The objective remission rate(48.48％)and disease control rate(81.82％)in study group were higher than those in control group(29.23％)and(60.00％)(P＜0.05).After treatment,carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),Th2,interleukin-4(IL-4),squamous cell carcinoma antigen(SCC-Ag)and miR-221 in study group were lower than those in control group(P＜0.05).After treatment,γ-interferon(IFN-γ),Th1 and miR-29b in study group were higher than those in control group(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Compare with chemotherapy alone,shenqi fuzheng injection can effectively reduce the level of tumor markers and improve the clinical efficacy in the treatment of advanced NSCLC patients,which may be relate to the improvement of immune function and the regulation of serum miR-29b and miR-221 expression levels.
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