Study on the Relationship between Serum Irisin,TMAO,MIF and the Prognosis of Patients with Chronic Heart Failure and Atrial Fibrillation and its Predictive Value
Objective:To investigate the relationship between serum irisin(Irisin),trimethylamine oxide(TMAO),macrophage migration inhibitory factor(MIF)and the prognosis of patients with chronic heart failure(CHF)and atrial fibrillation(AF)and its predictive value.Methods:175 patients with CHF and AF admitted to Gansu Provincial People's Hospital from January 2020 to January 2023 were selected and included in combined AF group,patints were divided into poor prognosis group and good prognosis group according to the prognosis.And 100 CHF patients without AF during the same period were included in non-combined AF group.The levels of serum Irisin,TMAO and MIF were detected by enzyme-linked immunosorbent assay.The prognostic influencing factors of patients with CHF and AF were analyzed by multivariate logistic regression,the predictive value of serum Irisin,TMAO and MIF in the poor prognosis of patients with CHF and AF were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with non-combined AF group,the serum Irisin level in AF group was decreased,and the serum TMAO and MIF levels were increased(P＜0.05).Compared with good prognosis group,the serum Irisin level in poor prognosis group was decreased,and the serum TMAO and MIF levels were increased(P＜0.05).After 6 months of follow-up,the incidence of poor prognosis in 175 patients with CHF and AF was 26.29％.Multivariate Logistic regression analysis showed that,New York Heart Association(NYHA)classification of cardiac functionⅢ～Ⅳ level and elevated N-terminal pro-B-type natriuretic peptide(NT-proBNP),TMAO,and MIF were independent risk factors for poor prognosis in patients with CHF and AF,and elevated Irisin was an independent protective factor(P＜0.05).ROC curve analysis showed that,the area under the curve(AUC)of serum Irisin,TMAO and MIF combined prediction for poor prognosis of patients with CHF and AF was 0.919,which was greater than 0.787,0.780 and 0.777 predicted by serum Irisin,TMAO and MIF alone.Conclusion:The level of serum Irisin in patients with CHF and AF was decreased,and the levels of TMAO and MIF were increased,which were closely relate to the poor prognosis.The combine detection of serum Irisin,TMAO and MIF levels had a high predictive value for the poor prognosis of patients with CHF and AF.
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