Clinical Study on the Biological Wave Early Comprehensive Rehabilitation Therapy Combined with Different Frequencies Repetitive Transcranial Magnetic Stimulation in the Treatment of Coma Patients with Severe Craniocerebral Injury
Objective:To observe the clinical study of biological wave early comprehensive rehabilitation therapy combined with different frequencies repetitive transcranial magnetic stimulation(rTMS)in the treatment of coma patients with severe craniocerebral injury.Methods:From January 2022 to April 2023,90 coma patients with severe craniocerebral injury in the Third Hospital of Shandong Province were selected.According to the random number table method,patients were divided into group A and group B,45 cases in each group,all patients were treated with biological wave early comprehensive rehabilitation therapy combine with rTMS,group A was given low frequency rTMS,and group B was given high frequency rTMS.The Disability Rating Scale(DRS)score,Glasgow Coma Scale(GCS)score,cerebral hemodynamic indexes[blood flow velocity(Vm),middle cerebral artery systolic peak velocity(Vs),pulsatility index(PI)],nerve cell factors[brain-derived neurotrophic factor(BDNF),glial fibrillary acidic protein(GFAP),S100-β,neuron-specific enolase(NSE)]and adverse reactions were compared in two groups before and after treatment.Results:After treatment,the GCS score in group B was higher than that in group A,and the DRS score was lower than that in group A(P＜0.05).After treatment,the Vm and Vs in group B were higher than those in group A,and the PI was lower than that in group A(P＜0.05).After treatment,BDNF in group B was higher than that in group A,and GFAP,S100-β and NSE were lower than those in group A(P＜0.05).The incidence of adverse reactions in group B was higher than that in group A(P＜0.05).Conclusion:Biological wave early comprehensive rehabilitation therapy combined with rTMS in the treatment of coma patients with severe craniocerebral injury has a certain wake-up effect,among which high frequency wake-up effect is better,and it can effectively regulate the level of nerve cell factors,improve the body's cerebral hemodynamics,and improve GCS and DRS scores.But the adverse reactions of high-frequency rTMS treatment are greater than those of low-frequency rTMS,which is worthy of clinical attention.
Biological wave early comprehensive rehabilitation therapyDifferent frequenciesRepetitive transcranial magnetic stimulationSevere craniocerebral injuryComaClinical study
NETL
NSTL
万方数据
