Study on the Effect of Furongtongmai Capsule Combined with Valsartan in Protecting Target Organ Injury in Patients with Essential Hypertension
Objective:To study the effect of Furong Tongmai capsule combined with valsartan in protecting the target organ injury in patients with essential hypertension.Methods:From May 2022 to April 2023,92 patients with essential hypertension admitted to Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province were divided into the placebo group(46 cases)treated with valsartan combined with placebo and the Furongtongmai group(46 cases)treated with valsartan combined with Furongtongmai capsule.The grouping method was random lottery,and all patients were treated for 12 weeks.The curative effects of the two groups after 12 weeks of treatment were counted,and the levels of serum cytokines,blood pressure control,cardiac and renal functions,carotid artery and cerebral blood flow were compared before and after 12 weeks of treatment.Results:After 12 weeks of treatment,the total effective rate of the Furongtongmai group was higher than that of the placebo group(P＜0.05).After 12 weeks of treatment,the levels of serum homocysteine(HCY),myeloperoxidase(MPO),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),serum creatinine(SCr),urinary microalbumin(mAlb),β2-microglobulin(β2-MG),diastolic pressure,systolic pressure and mean nocturnal diastolic pressure in the two groups.Left atrial diameter index(LADI),left ventricular mass index(LVMI),intima-media thickness of common carotid artery(CCA-IMT),intima-media thickness of internal carotid artery(ICA-IMT)and the number of carotid plaques decreased compared with those before treatment,and the Furongtongmai group was lower than the placebo group(P＜0.05).Left ventricular ejection fraction(LVEF),average blood flow velocity of left vertebral artery,right vertebral artery and basilar artery were higher than before treatment,and the Furongtongmai group was higher than the placebo group(P＜0.05).Conclusion:Furongtongmai Capsule combined with valsartan could regulate the level of serum cytokines in patients with essential hypertension,improve their heart and renal function,carotid intima-media thickness,increase cerebral blood flow velocity,relieve target organ injury,and had a good target organ protection effect and good curative effect.
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