Study on the Relationship between Serum FM,TAT,MIP-1αand Postpartum Venous Thromboembolism and its Predictive Value
Objective:To investigate the relationship between serum fibrin monomer(FM),thrombin-antithrombin complex(TAT),macrophage inflammatory protein-1α(MIP-1α)and postpartum venous thromboembolism(VTE)and its predictive value.Methods:Pregnant women with VTE after delivery in The Second Affiliated Hospital of Chengdu Medical College from December 2021 to December 2023 were included in VTE group(n=45),pregnant women without VTE after delivery in our hospital during the same period were included in non-VTE group(n=180)according to the 1:4 pairing method.Serum FM,TAT,MIP-1α and D-dimer(D-D)levels were detected by enzyme-linked immunosorbent assay(ELISA).The influencing factors of postpartum VTE were analyzed by multivariate Logistic regression analysis,and the predictive value of serum FM,TAT,MIP-1α and D-D levels for postpartum VTE were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with non-VTE group,the serum levels of FM,TAT,MIP-1α and D-D in VTE group were increased(P＜0.05).Multivariate Logistic regression analysis showed that,increased age,uterine-incision delivery and increased FM,TAT,MIP-1α,and D-D were independent risk factors for postpartum VTE(P＜0.05).ROC curve analysis showed that,the area under the curve of combined prediction of serum FM,TAT,MIP-1α and D-D levels for postpartum VTE was 0.911,which was greater than 0.748,0.755,0.722 and 0.592 predicted by serum FM,TAT,MIP-1α and D-D levels alone.Conclusion:The increase of serum FM,TAT and MIP-1α levels are independent risk factors for postpartum VTE,serum FM,TAT,MIP-1α combine with D-D has a high predictive value for postpartum VTE.
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