Predictive Value of Dynamic Contrast-Enhanced Magnetic Resonanceimaging Parameters Combined with CEA,NLR,and PLR for the Efficacy of Neoadjuvant Chemotherapy in Cervical Cancer Patients
Objective:To study the predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters combined with carcino-embryonic antigen(CEA),neutrophils and lymphocytes ratio(NLR),platelet-to-lymphocyte ratios(PLR)for the efficacy of neoadjuvant chemotherapy in cervical cancer patients.Methods:110 cases of cervical cancer patients who received radical hysterectomy treatment in Zhangjiakou First Hospital from May.2020 to May 2023 were selected and divided into effective group and ineffective group based on the treatment effect.The general data,DCE-MRI parameters,serum CEA and peripheral blood NLR and PLR of the effective group and ineffective group were compared.The predictive value of DCE-MRI parameters combined with serum CEA,peripheral blood NLR and PLR on the efficacy of neoadjuvant chemotherapy was analyzed by Receiver Operating Characteristic(ROC)curve.Results:Among the 110 patients selected,78 were in the effective group,and 32 were in the ineffective group.The contrast enhancement rate(CER)and transport constant(Ktrans)levels in the effective group were lower than those in the ineffective group(P＜0.05),but there were no significant differences in other DCE-MRI parameters rate constant(Kep),initial area under the gadolinium curve(IAUGC),percentage of extracellular space volume(Ve)and maximum slope(Maxslope)between the two groups(P＞0.05).The serum CEA and peripheral blood NLR and PLR in the effective group were significantly lower than those in the ineffective group(P＜0.05).CER,Ktrans combined with serum CEA and peripheral blood NLR and PLR had the best predictive value for the efficacy of neoadjuvant chemotherapy,with AUC was 0.896,and sensitivity was 0.915,specificity was 0.802,which were higher than each single detection.Conclusion:DCE-MRI parameters combined with CEA,NLR and PLR can help to improving predictive value of the efficacy of neoadjuvant chemotherapy in cervical cancer patients.
Dynamic contrast-enhanced magnetic resonance imagingCEANLRPLRCervical cancer
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