Study on the Relationship between Serum IL-6,Hcy,sFlt-1 and Cerebral Vasospasm after Clipping Operation in Patients with Intracranial Aneurysms
Objective:To investigate the relationship between serum interleukin-6(IL-6),homocysteine(Hcy)and soluble Fms-like tyrosine kinase 1(sFlt-1)and cerebral vasospasm(CVS)after clipping operation in patients with intracranial aneurysms(IAs).Methods:185 patients who underwent intracranial aneurysm clipping operation in the Affiliated Hospital of Xuzhou Medical University from July 2021 to July 2023 were selected as research objects,patients were divided into non-CVS group and CVS group according to the occurrence of CVS after operation.The levels of IL-6,Hey and sFlt-1 were detected by enzyme-linked immunosorbent assay.The risk factors of CVS after IAs clipping operation were analyzed by multivariate Logistic regression,the predictive value of serum IL-6,Hcy and sFlt-1 for CVS after IAs clipping operation were analyzed by receiver operating characteristic(ROC)curve.Results:43 patients had CVS after IAs clipping operation,and the incidence of CVS was 23.24％.The levels of serum IL-6,Hey and sFlt-1 in CVS group were significantly higher than those in non-CVS group(all P＜0.05).Multivariate Logistic regression analysis showed that elevated serum IL-6,Hey and sFlt-1,Hunt-Hess grade Ⅱ-Ⅲ,large aneurysm diameter and subarachnoid hemorrhage times 2 2 were independent risk factors for CVS after IAs clipping operation(P＜0.05).ROC curve results showed that the area under the curve(AUC)of serum IL-6,Hey and sFlt-1 in predicting CVS after IAs clipping operation was 0.939,which was higher than 0.768,0.825 and 0.826 predicted by serum IL-6,Hey and sFlt-1 alone.Conclusion:The levels of serum IL-6,Hey and sFlt-1 in patients with CVS after IAs clipping operation are significantly increase,and they are independent risk factors for postoperative CVS.The combine detection of serum IL-6,Hey and sFlt-1 has a high predictive value for CVS after IAs clipping operation.
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