The Effect of Tacrolimus Combined with Prednisone on Renal Function and Immune Function in Children with Primary Nephrotic Syndrome
Objective:To explore the changes in renal and immune function in children with primary nephrotic syndrome(PNS)after treatment with tacrolimus combined with prednisone.Methods:82 children with PNS admitted to Hebei Children's Hospital from June 2018 to July 2022 were divided into the group A and the group B by random number table method,41 cases in each group.The group A was given prednisone acetate tablets,and on the basis of treatment for the group A patients,tacrolimus capsules were used to treat the group B patients.The treatment time for both groups were 6 months.The renal function,immune function,blood lipid indicators,fibrinogen(FIB),C-reactive protein(CRP),microalbumin(U-mALb)and urinary N-acetyl-β-D-glucosaminidase(NAG)between the two groups before and after 6 months of treatment were compared.Results:Compared with before treatment,after 6 months of treatment,the levels of renal function indicators and serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),FIB,CRP and urine NAG,U-mALb in both groups decreased,and compared with the group A,the group B was lower;The levels of whole blood CD3+,CD4+,CD4+/CD8+,NK cells and serum high-density lipoprotein cholesterol(HDL-C)in the two groups increased,and compared with the group A,the levels in the group B were higher(P＜0.05).Conclusion:After treatment with tacrolimus combined with prednisone,the inflammatory response in PNS patients was significantly reduced,and their renal and immune functions were effectively improved.Levels of lood lipids and FIB were also regulated.
Primary nephrotic syndromePrednisoneTacrolimusRenal functionImmunity function
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