Analysis of the Influence Factors on the Effect and Prognosis of Different Doses of Agatroban Combined with Butylphthalein in Patients with Acute Cerebral Infarction
Objective:This study was to investigate the influence factors of different doses of agatroban combined with butylph-thalein on the effect and prognosis of patients with acute cerebral infarction.Methods:A total of 90 cases of emergency acute cerebral in-farction admitted to our hospital from June 2019 to August 2022 were studied,and they were divided into a high-dose group(receiving high-dose agattriban combined with butylphthalide)and a low-dose group(receiving low-dose agattriban combined with butylphthalide)with 45 cases in each group by random number table method.The clinical efficacy and prognosis of the two groups after 7 days of treat-ment were compared,and the neurological function[Chinese Stroke Scale(CSS)score and neurological function(NIHSS)score]of the two groups were analyzed before treatment and after 7 days of treatment.Patients were divided into good prognosis group and poor prog-nosis group according to different prognosis.Single/multifactor Logisitic regression was used to analyze the prognostic factors of acute cerebral infarction.Results:(1)The clinical efficacy of the two groups was included in the study and the difference between the groups was compared.The results showed that the total effective rate of the high-dose group was higher than that of the low-dose group(P＜0.05).(2)The neurological function of the two groups was evaluated by CSS score and NIHSS score,and the difference between the two groups was compared.The results showed that before treatment,CSS score and NIHSS score were compared between the two groups(P＞0.05).After 7 days of treatment,the CSS score and NIHSS score in the high-dose group were higher than those in the low-dose group(P＜0.05).(3)The prognosis of the two groups was included in the study using mRS Score assessment and the difference between the groups was compared.The results showed that the good prognosis of the high-dose group was 2.22％(1/45)higher than that of the low-dose group,15.56％(7/45)(P＜0.05).(4)Age of patients with good prognosis,pre-treatment CSS score and pre-treatment NIHSS score were different from the poor prognosis group(P＜0.05).(5)With the prognosis of acute cerebral infarction as the dependent variable and the indicators with differences in the single factor as the independent variable,the factors affecting the prognosis of acute cerebral infarction were CSS score before treatment and NIHSS score before treatment by multifactor Logisitic regression analysis.Conclusion:High-dose agatroban combined with butylphthalide can effectively treat patients with acute cerebral infarction,and the prognostic factors of acute cerebral infarction are CSS score before treatment and NIHSS score before treatment.
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